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Most cases arise in lymph nodes, although extranodal presentation is described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Clinical, radiological and histological characteristics, including diagnosis on pre\u2010resection material, were assessed in seven intrathoracic cases from five males and two females with a median age of 38\u00a0years. Clinical symptoms were related to mass location, six cases presenting within central and\/or posterior mediastinal compartments and one within the lungs. Positron emission tomography\u2013computed tomography demonstrated marked fluoro\u2010deoxy\u2010glucose avidity and the prominent vessels traversing the lesions. Four of six cases (67%) were misdiagnosed initially. <jats:styled-content style=\"fixed-case\">HVCD<\/jats:styled-content> was present in three cases. Two cases with high mitotic rates recurred after resection. All were positive for at least one of the follicular dendritic cell markers (CD21, CD35 and CD23). Six of seven cases (86%) show cyclin D1 expression ranging from 5% to 90%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Follicular dendritic cell sarcoma is often misdiagnosed on biopsy and pathologists need to be aware of the tumour to request the relevant immunohistochemistry, especially in masses presenting in the central\/posterior mediastinum with high vascularity and standardized uptake values. Background <jats:styled-content style=\"fixed-case\">HVCD<\/jats:styled-content> appears more common than previously thought.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.12998","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T16:00:14Z","timestamp":1464019214000},"page":"752-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Follicular dendritic cell tumour\/sarcoma: a commonly misdiagnosed tumour in the thorax"],"prefix":"10.1111","volume":"69","author":[{"given":"Patrizia","family":"Viola","sequence":"first","affiliation":[{"name":"Department of Histopathology Royal Brompton and Harefield NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M","family":"Vroobel","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Marsden Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Department of Imaging Royal Brompton and Harefield NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Royal Brompton and Harefield NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Ladas","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Royal Brompton and Harefield NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dusmet","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Royal Brompton and Harefield NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Montero","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Brompton and Harefield NHS Foundation Trust London UK"},{"name":"National Heart and Lung Institute Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Brompton and Harefield NHS Foundation Trust London UK"},{"name":"National Heart and Lung Institute Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C","family":"Wotherspoon","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Marsden Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Brompton and Harefield NHS Foundation Trust London UK"},{"name":"National Heart and Lung Institute Imperial College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01418.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199810)59:2<161::AID-AJH10>3.0.CO;2-C"},{"key":"e_1_2_7_4_1","first-page":"363","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Chan JKC","year":"2008"},{"key":"e_1_2_7_5_1","first-page":"562","article-title":"A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation. 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