{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T09:17:25Z","timestamp":1792315045490,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008718","name":"Judith Jane Mason and Harold Stannett Williams Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the spectrum of mutations in 20 genes involved in B\u2010cell receptor and\/or Toll\u2010like receptor signalling resulting in activation of nuclear factor\u2010\u03baB (NF\u2010\u03baB) in 20 nodal marginal zone lymphomas (NMZLs), 20 follicular lymphomas (FLs), and 11 cases of B\u2010cell lymphoma, unclassifiable (BCL\u2010u).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Nodal marginal zone lymphomas were diagnosed according to strict criteria, including the expression of at least one putative marginal zone marker (MNDA and\/or IRTA1). Cases that showed features of NMZL but did not fulfil all criteria were included as BCL\u2010u. All FLs were required to have a <jats:italic>BCL2<\/jats:italic> rearrangement. Mutations were found in: nine NMZLs, with recurrent mutations in <jats:italic>TNFAIP3<\/jats:italic> and <jats:italic>CD79B<\/jats:italic>; 12 FLs, with recurrent mutations in <jats:italic>TNFRSF14<\/jats:italic>,<jats:italic> TNFAIP3<\/jats:italic>, and <jats:italic>CARD11<\/jats:italic>; and five cases of BCL\u2010u, with recurrent mutations in <jats:italic>TNFRSF14<\/jats:italic>. <jats:italic>TNFRSF14<\/jats:italic> mutations were present in FL and BCL\u2010u, but not in any of the NMZLs. In the BCL\u2010u group, <jats:italic>TNFRSF14<\/jats:italic> mutations clustered with a FL immunophenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that <jats:italic>TNFRSF14<\/jats:italic> mutations point towards a diagnosis of FL, and can be used in the sometimes difficult distinction between NMZL and FL, but to apply this in diagnostics would require confirmation in an independent cohort. In addition, the presence or absence of specific mutations in pathways converging on NF\u2010\u03baB could be important for decisions regarding targeted treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13015","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T07:28:36Z","timestamp":1465889316000},"page":"174-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Recurrent mutations in genes involved in nuclear factor\u2010\u03baB signalling in nodal marginal zone lymphoma\u2014diagnostic and therapeutic implications"],"prefix":"10.1111","volume":"70","author":[{"given":"Michiel","family":"van den Brand","sequence":"first","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos","family":"Rijntjes","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konnie M","family":"Hebeda","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Menting","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn V","family":"Bregitha","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy B C","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Haematology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J F M","family":"van der Velden","sequence":"additional","affiliation":[{"name":"Department of Haematology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan B J","family":"Tops","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Han J M","family":"van Krieken","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J T A","family":"Groenen","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Centre Nijmegen The 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