{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:00:50Z","timestamp":1770537650925,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Reflux symptoms are highly prevalent and non\u2010specific; hence, in the absence of alarm symptoms, endoscopy referral decisions are challenging. This study evaluated whether a non\u2010endoscopic Cytosponge could detect benign oesophageal pathologies and thus have future potential in triaging patients with persistent symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Two complementary cohorts were recruited: (i) patients with reflux symptoms and no prior endoscopy (<jats:italic>n<\/jats:italic> = 409), and (ii) patients with reflux symptoms referred for endoscopy (<jats:italic>n<\/jats:italic> = 411). All patients were investigated using the Cytosponge and endoscopy. Significant epithelial inflammation was present in 130 (16%) Cytosponge samples, 32 of which had ulcer slough. Candida and significant inflammation was detected in a further 22 (2.3%) cases; epithelial infiltration with &gt;15 eosinophils\/high\u2010power field reflecting possible eosinophilic oesophagitis (<jats:styled-content style=\"fixed-case\">EOE<\/jats:styled-content>) in five (0.6%); and viral inclusions suggestive of herpes oesophagitis in one (0.1%). No significant pathology was detected in the majority, 662 (81%), of Cytosponge samples. Cytosponge and endoscopy findings were in agreement in 574 (70%) cases, in 165 (67%) of the discordant cases one investigation showed mild inflammation while the other was negative, with an additional 22 (8.9%) differing on the extent of inflammation. Eighteen cases with severe inflammation, six with candida and two with <jats:styled-content style=\"fixed-case\">EOE<\/jats:styled-content> were detected only at endoscopy, while 18 with candida and significant inflammation, 13 with ulcer slough, one probable <jats:styled-content style=\"fixed-case\">EOE<\/jats:styled-content> and one viral oesophagitis were identified on the Cytosponge only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Cytosponge detects a range of benign oesophageal pathologies, and therefore has potential clinical utility in the triaging of patients with troublesome reflux symptoms. This warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13039","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T05:16:26Z","timestamp":1468559786000},"page":"203-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Range of pathologies diagnosed using a minimally invasive capsule sponge to evaluate patients with reflux symptoms"],"prefix":"10.1111","volume":"70","author":[{"given":"Anna L","family":"Paterson","sequence":"first","affiliation":[{"name":"MRC Cancer Unit Hutchison\u2010MRC Research Centre Cambridge UK"},{"name":"Department of Histopathology Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Lao\u2010Sirieix","sequence":"additional","affiliation":[{"name":"MRC Cancer Unit Hutchison\u2010MRC Research Centre Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"O'Donovan","sequence":"additional","affiliation":[{"name":"MRC Cancer Unit Hutchison\u2010MRC Research Centre Cambridge UK"},{"name":"Department of Histopathology Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Debiram\u2010Beecham","sequence":"additional","affiliation":[{"name":"MRC Cancer Unit Hutchison\u2010MRC Research Centre Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"di Pietro","sequence":"additional","affiliation":[{"name":"MRC Cancer Unit Hutchison\u2010MRC Research Centre Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Miremadi","sequence":"additional","affiliation":[{"name":"MRC Cancer Unit Hutchison\u2010MRC Research Centre Cambridge UK"},{"name":"Department of Histopathology Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E","family":"Attwood","sequence":"additional","affiliation":[{"name":"Department of Surgery North Tyneside Hospital North Shields UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona M","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D","family":"Sasieni","sequence":"additional","affiliation":[{"name":"Cancer Prevention Trials Unit Wolfson Institute of Preventative Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca C","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"MRC Cancer Unit Hutchison\u2010MRC Research Centre Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the BEST and BEST2 study groups","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32978"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.444"},{"key":"e_1_2_7_6_1","volume-title":"Dyspepsia and gastro\u2010oesophageal reflux disease","author":"National Institute for Health and Care Excellence (NICE)","year":"2014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04406.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305372"},{"key":"e_1_2_7_9_1","unstructured":"National Institute for Health and Care Excellence (NICE).Suspected cancer: recognition and referral. 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