{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:36:32Z","timestamp":1778819792996,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JSPS KAKENHI","award":["25460448"],"award-info":[{"award-number":["25460448"]}]},{"name":"JSPS KAKENHI","award":["16K08680"],"award-info":[{"award-number":["16K08680"]}]},{"name":"Tokyo Metropolitan Hospitals"},{"name":"National Cancer Center Research and Development Fund","award":["26-A-21"],"award-info":[{"award-number":["26-A-21"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Although desmoplastic fibroblastoma (<jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content>) and fibroma of tendon sheath (<jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content>) are well\u2010established entities, they may show overlapping clinicopathological features. In addition, cytogenetic data showing a shared 11q12 rearrangement in a small number of cases suggest a close link between these entities. A recent microarray study revealed up\u2010regulation of <jats:italic><jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1<\/jats:italic> m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content>s with 11q12 rearrangement. The aim of this study was to clarify the relationship between <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We tested 42 cases diagnosed originally as either <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content>s or <jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content>s for interobserver concordance based on the existing histological criteria and correlated the diagnosis with <jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1 immunohistochemistry. In addition, <jats:italic><jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1<\/jats:italic> gene status was determined by chromogenic <jats:italic>in\u2010situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">CISH<\/jats:styled-content>). Using joint histological evaluation, 41 of 42 tumours were classified unanimously by three pathologists into 25 <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content>s and 16 <jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content>s, whereas only one case received discordant opinions. Immunohistochemically, all <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content>s showed diffuse, strong <jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1 nuclear immunoreactivity (25 of 25, 100%), while none of the <jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content>s showed such overexpression. None of the selected 42 <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content> mimics overexpressed <jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1. <jats:italic><jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1<\/jats:italic> was not rearranged in seven <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content>s tested by <jats:styled-content style=\"fixed-case\">CISH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We confirm here that <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FTS<\/jats:styled-content> are two distinct entities that can be distinguished using the existing histological criteria. This distinction corresponds perfectly with <jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1 immunohistochemical expression status, and diffuse strong <jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1 expression specific to <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content>s sharpens the border between the two categories. <jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1 overexpression in <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content> may not be caused directly by <jats:italic><jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1<\/jats:italic> gene rearrangement. <jats:styled-content style=\"fixed-case\">FOSL<\/jats:styled-content>1 may also be a diagnostic aid for differentiating <jats:styled-content style=\"fixed-case\">DFB<\/jats:styled-content> from other histological mimics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13042","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T14:36:56Z","timestamp":1469111816000},"page":"1012-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["FOSL1 immunohistochemistry clarifies the distinction between desmoplastic fibroblastoma and fibroma of tendon sheath"],"prefix":"10.1111","volume":"69","author":[{"given":"Ikuma","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Tokyo Japan"},{"name":"Department of Molecular Pathology Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories National Cancer Center Central 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