{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T09:06:59Z","timestamp":1774084019353,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To review the clinicopathological features of 14 cases of <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> 3\u2010like squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) of the cervix and to investigate possible mechanisms of tumour invasion in the <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> 3\u2010like and \u2018conventional\u2019 (infiltrative) tumour components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The median patient age was 43.4 years. Of the 12 cases with known stage, eight were stage <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> and four were stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. Initial biopsies were often misinterpreted as <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> 3 alone or <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> 3 with only superficial stromal invasion, and eight patients underwent multiple biopsy procedures prior to definitive diagnosis: upon review, an earlier diagnosis was possible in six of these cases. Nine tumours exhibited both <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> 3\u2010like and conventional tumour components. The former usually demonstrated an E\u2010cadherin\u2010positive and cyclin D1\u2010negative immunophenotype, whereas conventional <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> more often showed loss of E\u2010cadherin and cyclin D1 staining at the margin of larger tumour nests and in smaller invasive clusters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cervical <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>s demonstrating a <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> 3\u2010like growth pattern continue to present diagnostic difficulty and are often misinterpreted as non\u2010invasive\/minimally invasive disease. The morphology and immunophenotype suggest a process of collective cellular invasion in <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content> 3\u2010like <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>, whereas corresponding conventional <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> elements show features consistent with epithelial\u2013mesenchymal transition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13094","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T15:32:54Z","timestamp":1475076774000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cervical intraepithelial neoplasia (<scp>CIN<\/scp>) 3\u2010like squamous cell carcinoma of the cervix: a review of 14 cases with comparison of E\u2010cadherin and cyclin D1 expression in the <scp>CIN<\/scp> 3\u2010like and infiltrative tumour elements"],"prefix":"10.1111","volume":"70","author":[{"given":"Colin J R","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Pathology King Edward Memorial Hospital Perth Western Australia Australia"},{"name":"School of Womens\u2019 and Infant's Health University of Western Australia Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxine L","family":"Crook","sequence":"additional","affiliation":[{"name":"Department of Pathology King Edward Memorial Hospital Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr015"},{"key":"e_1_2_6_3_1","first-page":"172","volume-title":"WHO classification of tumours of female reproductive organs","author":"Stoler M","year":"2014"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Epithelial\u2013mesenchymal transition in cervical carcinoma","volume":"4","author":"Lee M\u2010Y","year":"2012","journal-title":"Am. 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