{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:19:16Z","timestamp":1783473556024,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA62924"],"award-info":[{"award-number":["P50 CA62924"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Gastric pyloric gland adenomas (<jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s) are rare epithelial polyps that are found more commonly in autoimmune atrophic gastritis and familial adenomatous polyposis (FAP). Little is known about the morphology and genetics of <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> are studied morphologically and genetically. Findings in <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s are compared to sporadic <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s and related lesions such as oxyntic gland adenoma (<jats:styled-content style=\"fixed-case\">OGA<\/jats:styled-content>) to increase our understanding of these rare polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Seven <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s and 18 fundic gland polyps (<jats:styled-content style=\"fixed-case\">FGP<\/jats:styled-content>s) from <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> patients were collected. <jats:italic><jats:styled-content style=\"fixed-case\">KRAS<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content><\/jats:italic> mutations were determined in six <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s and 18 <jats:styled-content style=\"fixed-case\">FGP<\/jats:styled-content>s. Immunohistochemistry was applied on five <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s to provide further confirmation of the histological subtypes and genetic alterations. Morphology of all <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s was studied and compared to literature on sporadic <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s and related lesions. All successfully sequenced <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s (six of six) carried <jats:italic><jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content><\/jats:italic> mutations and half of the successfully sequenced <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s carried a <jats:italic><jats:styled-content style=\"fixed-case\">KRAS<\/jats:styled-content><\/jats:italic> mutation (three of six). Nuclear \u03b2\u2010catenin was seen only in one <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content> with focal high\u2010grade dysplasia. Morphologically, <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> showed overlapping features with <jats:styled-content style=\"fixed-case\">OGA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Familial adenomatous polyposis\u2010associated <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s have a similar genetic background as sporadic <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s, i.e. <jats:italic><jats:styled-content style=\"fixed-case\">KRAS<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">GNAS<\/jats:styled-content><\/jats:italic> mutation. Based on morphological findings in <jats:styled-content style=\"fixed-case\">FAP<\/jats:styled-content> associated <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s, it is hypothesized that <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">OGA<\/jats:styled-content>s are closely related lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13105","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T10:07:35Z","timestamp":1477044455000},"page":"549-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis"],"prefix":"10.1111","volume":"70","author":[{"given":"Wenzel M","family":"Hackeng","sequence":"first","affiliation":[{"name":"Department of Pathology University Medical Center Utrecht Utrecht the 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