{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:16:11Z","timestamp":1787584571869,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>The World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification, and incorporated the most up\u2010to\u2010date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of germ cell tumours; however, several modifications were also made for non\u2010germ cell tumours. Among sex cord\u2013stromal tumours, sclerosing Sertoli cell tumour (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) is no longer recognized as a separate entity but as a morphological variant of <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> not otherwise specified (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>), as <jats:italic><jats:styled-content style=\"fixed-case\">CTNNB<\/jats:styled-content>1<\/jats:italic> gene mutations have been noted in both neoplasms but not in the other forms of <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>. Similarly, the lipid cell variant is not separately classified, but is considered to be a morphological variant of <jats:styled-content style=\"fixed-case\">SCT NOS<\/jats:styled-content>. Large\u2010cell calcifying <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> is recognized as a distinct entity that occurs either sporadically or in association with Carney complex, with the latter patients having a distinct germline <jats:italic><jats:styled-content style=\"fixed-case\">PRKAR<\/jats:styled-content>1A<\/jats:italic> gene mutation. Intratubular large\u2010cell hyalinizing Sertoli cell neoplasia is also accepted as a separate entity linked with Peutz\u2013Jeghers syndrome. The subcategories of \u2018mixed\u2019 and \u2018incompletely differentiated\u2019 forms of sex cord\/gonadal stromal tumours have been replaced by \u2018mixed and unclassified sex cord\u2013stromal tumours\u2019. New entities introduced in the latest <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> revision include: myoid gonadal stromal tumour and \u2018undifferentiated gonadal tissue\u2019, a putative precursor lesion of gonadoblastoma, whereas juvenile xanthogranuloma and haemangioma are included in the miscellaneous category of tumours.<\/jats:p>","DOI":"10.1111\/his.13115","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T17:32:15Z","timestamp":1482600735000},"page":"513-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["The World Health Organization 2016 classification of testicular non\u2010germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel"],"prefix":"10.1111","volume":"70","author":[{"given":"Muhammad T","family":"Idrees","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Ulbright","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Oliva","sequence":"additional","affiliation":[{"name":"Pathology Department Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H","family":"Young","sequence":"additional","affiliation":[{"name":"Pathology Department Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Montironi","sequence":"additional","affiliation":[{"name":"Department of Pathology Universit\u00e0 Politecnica delle Marche Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Egevad","sequence":"additional","affiliation":[{"name":"Department of Pathology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Berney","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology Barts Cancer Institute Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Srigley","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan I","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins Hospital Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish K","family":"Tickoo","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Members of the International Society of Urological Pathology Testicular Tumour Panel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"World Health Organization classification of tumours. 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