{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:43:39Z","timestamp":1789685019711,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004721","name":"University of Tokyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Malignant mesothelioma is a highly aggressive cancer that is usually diagnosed at advanced stages; thus, highly sensitive and specific markers are necessary for its early definitive diagnosis. The aim of this study was to evaluate the diagnostic utility and prognostic significance of <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 in malignant mesothelioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The expression of <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 was investigated by immunohistochemistry in 32 malignant mesotheliomas and 44 benign mesothelial proliferative lesions, including well\u2010differentiated papillary mesothelioma (<jats:italic>n<\/jats:italic> = 4), mesothelial inclusion cyst (<jats:italic>n<\/jats:italic> = 22), and reactive mesothelial hyperplasia (<jats:italic>n<\/jats:italic> = 18). <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 loss and high <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 expression were observed in 17 (53%) and 22 (66%) malignant mesothelioma cases, respectively, whereas none of the benign lesions showed <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 loss or high <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 expression. The combination of <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 loss and high <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 expression as markers to differentiate epithelioid\/biphasic malignant mesothelioma from benign mesothelial lesions was highly sensitive (90%) and specific (100%). There were no statistically significant associations between parameters such as age and sex of patients, tumour location, asbestos exposure, treatment, histology, and <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 or <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 expression. Survival analysis revealed that <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 loss, but not high <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 expression, was associated with a better prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 loss and high <jats:styled-content style=\"fixed-case\">EZH<\/jats:styled-content>2 expression were highly specific to malignant mesothelioma in differentiating it from benign mesothelial proliferations, and the combination of these two markers improved the diagnostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13123","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T08:15:05Z","timestamp":1479284105000},"page":"722-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Diagnostic utility of <scp>BAP<\/scp>1 and <scp>EZH<\/scp>2 expression in malignant mesothelioma"],"prefix":"10.1111","volume":"70","author":[{"given":"Aya","family":"Shinozaki\u2010Ushiku","sequence":"first","affiliation":[{"name":"Department of Pathology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Ushiku","sequence":"additional","affiliation":[{"name":"Department of Pathology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Pathology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Anraku","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fukayama","sequence":"additional","affiliation":[{"name":"Department of Pathology Graduate School of Medicine The University of Tokyo Tokyo 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