{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:02:43Z","timestamp":1788958963095,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01CA124633"],"award-info":[{"award-number":["2R01CA124633"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NUT<\/jats:styled-content> midline carcinoma (<jats:styled-content style=\"fixed-case\">NMC<\/jats:styled-content>) is a rare undifferentiated and aggressive carcinoma that locates characteristically to the midline of the head and neck, and mediastinum. <jats:styled-content style=\"fixed-case\">NMC<\/jats:styled-content> is characterized by chromosomal rearrangements of the gene <jats:italic><jats:styled-content style=\"fixed-case\">NUT<\/jats:styled-content><\/jats:italic>, at 15q14. The <jats:italic><jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>4<\/jats:italic> gene on 19q13 is the most common translocation partner forming a fusion oncogene, <jats:italic><jats:styled-content style=\"fixed-case\">BRD<\/jats:styled-content>4\u2013<jats:styled-content style=\"fixed-case\">NUT<\/jats:styled-content><\/jats:italic>. By the end of 2014, the International <jats:styled-content style=\"fixed-case\">NUT<\/jats:styled-content> Midline Carcinoma Registry had 48 patients treated for <jats:styled-content style=\"fixed-case\">NMC<\/jats:styled-content>. Laryngeal <jats:styled-content style=\"fixed-case\">NMC<\/jats:styled-content> are exceedingly rare, and we report a case series of seven cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We searched for cases in files of different hospitals as well as a thorough search of the English language literature. The diagnosis of <jats:styled-content style=\"fixed-case\">NMC<\/jats:styled-content> is made by demonstration of <jats:italic><jats:styled-content style=\"fixed-case\">NUT<\/jats:styled-content><\/jats:italic> rearrangement either by immunohistochemistry, fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) or reverse transcription\u2013polymerase chain reaction (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>). We found three previously published cases, and in this series add four cases of our own.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NMC<\/jats:styled-content> consists of monomorphic, often discohesive, cells with an epithelioid appearance and distinct nucleoli. The tumours typically show abrupt squamous differentiation. The mean age of the patients was 34 years, hence significantly lower than that for conventional laryngeal carcinoma. All tumours were located in the supraglottis and five patients died of the disease after 3, 7, 8, 9 and 11 months. Laryngeal <jats:styled-content style=\"fixed-case\">NMC<\/jats:styled-content> may be underdiagnosed, and an increased awareness among pathologists is warranted. <jats:styled-content style=\"fixed-case\">NMC<\/jats:styled-content> has characteristic morphological features, and positive immunostaining with the <jats:styled-content style=\"fixed-case\">NUT<\/jats:styled-content> antibody is diagnostic. Its aggressive behaviour demands a very intense treatment strategy and the need for its recognition is emphasized further by new promising treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13143","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T21:06:42Z","timestamp":1481144802000},"page":"861-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["<scp>NUT<\/scp> midline carcinoma of the larynx: an international series and review of the literature"],"prefix":"10.1111","volume":"70","author":[{"given":"Henrik","family":"Hellquist","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Medicine University of Algarve Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"French","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Boston MA 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