{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:26:38Z","timestamp":1776997598110,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Education, Taiwan, ROC","award":["EMRPD1F0021"],"award-info":[{"award-number":["EMRPD1F0021"]}]},{"name":"Chang Gung Medical Research Program","award":["CMRPG3E0342"],"award-info":[{"award-number":["CMRPG3E0342"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To characterize the clinicopathological and genetic features of pleomorphic mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content>), which morphologically mimics diffuse large B cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We screened systematically 500 B cell lymphomas morphologically compatible with <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> using an immunohistochemical algorithm of three markers (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5, cyclin D1 and <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11). Ten cases of <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content> were identified for further study and, surprisingly, four (40%) of them were cyclin D1\u2010negative. These 10 patients were mainly elderly males with advanced disease, and their median survival was only 11 months. All cyclin D1\u2010positive <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content>s tested showed an <jats:italic><jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content><\/jats:italic>\u2013<jats:italic><jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>1<\/jats:italic> translocation, whereas one of the four cyclin D1\u2010negative <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content>s had a translocation involving <jats:italic><jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>2<\/jats:italic> and a high <jats:italic><jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>2 <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level (<jats:italic>P<\/jats:italic> &lt; 0.000001). The genomewide copy number profiles of both cyclin D1\u2010positive and cyclin D1\u2010negative <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content>s were similar to those of classical mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>) reported previously, confirming the diagnosis. Secondary genetic alterations involved in oncogenic pathways of <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content> were observed more frequently in these <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content>s, possibly decreasing the dependence on the driving <jats:italic><jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>1<\/jats:italic> translocation and accounting for the common cyclin D1 negativity. Copy number gains of <jats:italic><jats:styled-content style=\"fixed-case\">PIK<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">CCDC<\/jats:styled-content>50<\/jats:italic> were detected in all cyclin D1\u2010negative <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content>s but in only 40% of the cyclin D1\u2010positive <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content>s. These additional oncogenic signals may compensate for the common absence of <jats:italic><jats:styled-content style=\"fixed-case\">CCND<\/jats:styled-content>2<\/jats:italic> translocation in cyclin D1\u2010negative <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrate for the first time that cyclin D1 negativity is surprisingly common in <jats:styled-content style=\"fixed-case\">PMCL<\/jats:styled-content> morphologically mimicking <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, and the use of a simple immunohistochemical algorithm can prevent misclassification and inappropriate treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13161","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T14:33:13Z","timestamp":1483021993000},"page":"986-999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall"],"prefix":"10.1111","volume":"70","author":[{"given":"Wen\u2010Yu","family":"Chuang","sequence":"first","affiliation":[{"name":"Department of Pathology Chang Gung Memorial Hospital and Chang Gung University College of Medicine Taoyuan Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Center for Vascularized Composite Allotransplantation Chang Gung Memorial Hospital Taoyuan 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