{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:11:33Z","timestamp":1792710693757,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Pulmonary adenofibromas are rare benign fibroepithelial tumours of the lung with unknown histogenesis and an indolent clinical behaviour. Their stroma resembles that of solitary fibrous tumours, whereas the glands are composed of respiratory epithelium organized in a phyllodes\u2010like architecture. Differentiation of pulmonary adenofibromas from other more aggressive intrathoracic tumours is clinically relevant. However, their biology is unknown. Here, we sought to characterize pulmonary adenofibromas at a clinicopathological level and to define whether they could be underpinned by a highly recurrent somatic genetic alteration akin to tumours with similar morphology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Seven pulmonary adenofibromas were subjected to immunohistochemical analysis for thyroid transcription factor 1 (\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      1), napsin A, cytokeratin 7, E\u2010cadherin,\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      99,\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      34,\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      31,\n                      <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                      6, oestrogen receptor (\n                      <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                      ), progesterone receptor, androgen receptor, bcl\u20102, and vimentin, as well as electron microscopy and capillary sequencing on microdissected samples to evaluate the presence of\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">NAB<\/jats:styled-content>\n                        2\n                      <\/jats:italic>\n                      \u2013\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                        6\n                      <\/jats:italic>\n                      fusion genes and\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>\n                        12\n                      <\/jats:italic>\n                      exon 2 mutations in their discrete components. A control group comprising pulmonary solitary fibrous tumours, pulmonary hamartomas and breast fibroadenomas was also analysed. We confirmed that the stromal elements of pulmonary adenofibromas pertain to the fibroblastic lineage, and show\n                      <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\n                      overexpression in 71% of cases, whereas the epithelium consists of\n                      <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                      1\u2010positive, E\u2010cadherin positive bronchiolar elements. A highly recurrent\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">NAB<\/jats:styled-content>\n                        2\n                      <\/jats:italic>\n                      \u2013\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                        6\n                      <\/jats:italic>\n                      fusion variant (exon 4\u2013exon 2) was detected in the stroma but not in the epithelium. No\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">MED<\/jats:styled-content>\n                        12\n                      <\/jats:italic>\n                      mutations were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring the molecular hallmark of solitary fibrous tumours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.13165","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T10:31:42Z","timestamp":1484044302000},"page":"906-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Recurrent\n                    <i>\n                      <scp>NAB<\/scp>\n                      2\n                    <\/i>\n                    \u2013\n                    <i>\n                      <scp>STAT<\/scp>\n                      6\n                    <\/i>\n                    gene fusions and oestrogen receptor\u2010\u03b1 expression in pulmonary adenofibromas"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-9131","authenticated-orcid":false,"given":"Nicola","family":"Fusco","sequence":"first","affiliation":[{"name":"Division of Pathology Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milan Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Guerini\u2010Rocco","sequence":"additional","affiliation":[{"name":"Division of Pathology European Institute of Oncology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Augello","sequence":"additional","affiliation":[{"name":"Division of Pathology Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milan Italy"},{"name":"Department of Pathophysiology and Organ Transplantation University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-3346","authenticated-orcid":false,"given":"Andrea","family":"Terrasi","sequence":"additional","affiliation":[{"name":"Division of Pathology Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milan Italy"},{"name":"Department of Pathophysiology and Organ Transplantation University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ercoli","sequence":"additional","affiliation":[{"name":"Division of Pathology Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Division of Pathology European Institute of Oncology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Vacirca","sequence":"additional","affiliation":[{"name":"Division of Pathology European Institute of Oncology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Braidotti","sequence":"additional","affiliation":[{"name":"Division of Pathology San Paolo Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Parafioriti","sequence":"additional","affiliation":[{"name":"Department of Pathology Orthopaedic Institute Gaetano Pini Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Jaconi","sequence":"additional","affiliation":[{"name":"School of Pathology University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letterio","family":"Runza","sequence":"additional","affiliation":[{"name":"Division of Pathology Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalakshmi","family":"Ananthanarayanan","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center Maywood, Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pagni","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Milan\u2010Bicocca Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Bosari","sequence":"additional","affiliation":[{"name":"Division of Pathology Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milan Italy"},{"name":"Department of Pathophysiology and Organ 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