{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T03:04:42Z","timestamp":1776654282531,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The lung lesion [immunoglobulin (Ig)G4\u2010L] of IgG4\u2010related disease (IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>) is a condition that occurs together with IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> and often mimics the lung lesion [idiopathic multicentric Castleman's disease (<jats:styled-content style=\"fixed-case\">iMCD<\/jats:styled-content>\u2010L)] of idiopathic multicentric Castleman's disease (<jats:styled-content style=\"fixed-case\">iMCD<\/jats:styled-content>). Because no clinical and pathological studies had previously compared features of these diseases, we undertook this comparison with clinical and histological data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Nine patients had IgG4\u2010L (high levels of serum IgG4 and of IgG4<jats:sup>+<\/jats:sup> cells in lung specimens; typical extrapulmonary manifestations). Fifteen patients had <jats:styled-content style=\"fixed-case\">iMCD<\/jats:styled-content>\u2010L (polyclonal hyperimmunoglobulinaemia, elevated serum interleukin\u20106 levels and polylymphadenopathy with typical lymphadenopathic lesions). Mean values for age, serum haemoglobin levels and IgG4\/IgG ratios were higher in the IgG4\u2010L group and C\u2010reactive protein levels were higher in the <jats:styled-content style=\"fixed-case\">iMCD<\/jats:styled-content>\u2010L group. All IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> lung lesions showed myxomatous granulation\u2010like fibrosis (active fibrosis), with infiltration of lymphoplasmacytes and scattered eosinophils within the perilymphatic stromal area, such as interlobular septa and pleura with obstructive vasculitis. All 15 lung lesions of <jats:styled-content style=\"fixed-case\">iMCD<\/jats:styled-content>, however, had marked accumulation of polyclonal lymphoplasmacytes in lesions with lymphoid follicles and dense fibrosis, mainly in the alveolar area adjacent to interlobular septa and pleura without obstructive vasculitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although both lesions had lymphoplasmacytic infiltration, lung lesions of IgG4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> were characterized by active fibrosis with eosinophilic infiltration within the perilymphatic stromal area with obstructive vasculitis, whereas lung lesions of <jats:styled-content style=\"fixed-case\">iMCD<\/jats:styled-content> had lymphoplasmacyte proliferating lesions mainly in the alveolar area adjacent to the perilymphatic stromal area. These clinicopathological features may help to differentiate the two diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13186","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T21:08:50Z","timestamp":1487279330000},"page":"1114-1124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Comparison of clinical and pathological features of lung lesions of systemic IgG4\u2010related disease and idiopathic multicentric Castleman's disease"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-7982","authenticated-orcid":false,"given":"Yasuhiro","family":"Terasaki","sequence":"first","affiliation":[{"name":"Department of Analytic Human Pathology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Ikushima","sequence":"additional","affiliation":[{"name":"Department of Respiratory 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