{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:41:33Z","timestamp":1761709293168,"version":"3.37.3"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T00:00:00Z","timestamp":1493164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Hairy cell leukaemia (<jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>) is a rare B cell neoplasm that mainly affects bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>), peripheral blood (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) and spleen. Involvement of lymph nodes and extranodal structures is considered infrequent. Herein we describe our institutional experience of nodal (<jats:italic>n<\/jats:italic> = 10) and extranodal (<jats:italic>n<\/jats:italic> = 3) <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> during a 30\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Ten patients had prior evidence of <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> within the <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content> at a median 35.8 months before nodal\/extranodal diagnosis (range: &lt;1\u2013175 months), and <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> was diagnosed concurrently within the bone marrow of one additional patient. Nodal involvement showed distinct architectural patterns, including diffuse (62% of cases), sinusoidal (25%) and nodular (13%). Extranodal involvement was characterized as diffuse infiltration through underlying structures in all cases. Morphological features ranged from classic \u2018fried\u2010egg\u2019 cytology to a plasmacytoid appearance. Nodal\/extranodal disease showed an overlapping immunophenotypical profile with other small B cell lymphomas, including expression of cyclin D1 (70%), <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>43 (55%), <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10 (38%) and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 (8%). Rates of both <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>43 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10 reactivity were higher than described previously in leukaemic <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content>, suggesting that expression may be enriched in cases with extramedullary extension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although uncommon, <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> should be considered in the differential diagnosis of small B cell neoplasms involving nodal\/extranodal sites, given the therapeutic implications. In particular, recent discoveries including detection of the <jats:styled-content style=\"fixed-case\"><jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V<\/jats:italic><\/jats:sup><\/jats:styled-content><jats:sup><jats:italic>600E<\/jats:italic><\/jats:sup> mutation in nearly all cases of <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> and the availability of an antibody to <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>103 for use in paraffin\u2010embedded tissues will facilitate the distinction of <jats:styled-content style=\"fixed-case\">HCL<\/jats:styled-content> from other small B cell lymphomas in the nodal\/extranodal setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13206","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T08:06:37Z","timestamp":1488787597000},"page":"112-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Morphological and immunophenotypical features of hairy cell leukaemia involving lymph nodes and extranodal tissues"],"prefix":"10.1111","volume":"71","author":[{"given":"Jacqueline M","family":"Cortazar","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J","family":"DeAngelo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine S","family":"Pinkus","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-9337","authenticated-orcid":false,"given":"Elizabeth A","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014209"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182549b50"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.1001988"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V53.3.412.412"},{"key":"e_1_2_7_6_1","first-page":"370","article-title":"Autopsy findings in hairy cell leukemia","volume":"11","author":"Vardiman JW","year":"1984","journal-title":"Semin. 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