{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:01:56Z","timestamp":1784779316907,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Secretory breast carcinoma is a rare, low\u2010grade, translocation\u2010associated invasive carcinoma with unique morphology and excellent prognosis. Three patterns (microcystic, tubular, solid) have often been described in secretory carcinoma. Herein, we reported one case of secretory breast carcinoma with an uncommon papillary\u2010predominant growth pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The patient was a 53\u2010year\u2010old female with a mass located in outer upper quadrant of her right breast. The patient had one positive axillary lymph node. Morphologically, tumour cells were arranged in a papillary growth pattern with sclerosis in most areas; glandular and microcystic patterns were observed only in focal areas at the periphery. The presence of intracellular and extracellular secretory material was observed. Tumour cells were mild\u2010to\u2010moderately atypical with granular eosinophilic to foamy cytoplasm. Tumour cells were triple\u2010negative [negative for oestrogen receptor (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>), progestogen receptor (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) and human epidermal growth factor receptor 2 (<jats:styled-content style=\"fixed-case\">HER<\/jats:styled-content>2)] with a basal\u2010like phenotype, and strongly positive for S\u2010100 protein. P63 and calponin staining showed the absence of myoepithelial cells around tumour cells. Fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) analysis showed <jats:styled-content style=\"fixed-case\">ETS<\/jats:styled-content> variant 6 (<jats:styled-content style=\"fixed-case\">ETV<\/jats:styled-content>6) gene rearrangement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study indicated that besides typical growth patterns (microcystic, solid and tubular), secretory carcinoma could also present with a papillary\u2010predominant architecture. These cases should be differentiated from other breast tumours with a papillary pattern. It may have clinical significance to recognize this uncommon morphology variant of secretory carcinoma in routine practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13232","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T18:27:23Z","timestamp":1491503243000},"page":"488-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Secretory breast carcinoma with a papillary\u2010predominant pattern: an unusual morphological variant"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-1741","authenticated-orcid":false,"given":"Ruohong","family":"Shui","sequence":"first","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-1105","authenticated-orcid":false,"given":"Yufan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianming","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1966.03100050096033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800501)45:9<2404::AID-CNCR2820450928>3.0.CO;2-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00180-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2004.01.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-3-35"},{"key":"e_1_2_6_7_1","volume-title":"WHO classification of tumours of the breast","author":"Lakhani SR","year":"2012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000392"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1701-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.190"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2010-0351-RS"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12172"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00423-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.184"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d9efcc"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.09.012"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318231542a"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0455-y"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198010000-00006"},{"key":"e_1_2_6_20_1","first-page":"457","article-title":"Juvenile secretory carcinoma and juvenile papillomatosis","volume":"15","author":"Tokunaga M","year":"1985","journal-title":"Jpn. 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