{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:27:55Z","timestamp":1792798075238,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HI14C2321"],"award-info":[{"award-number":["HI14C2321"]}],"id":[{"id":"https:\/\/ror.org\/00vxgjw72","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HI14C3365"],"award-info":[{"award-number":["HI14C3365"]}],"id":[{"id":"https:\/\/ror.org\/00vxgjw72","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Basic Science Research Programme through the NRF","award":["2015R1A2A1A15054754"],"award-info":[{"award-number":["2015R1A2A1A15054754"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the distinct histopathological characteristics and their clinical significance between non\u2010Hunner\u2010type and Hunner\u2010type interstitial cystitis (IC)\/bladder pain syndrome (BPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We prospectively enrolled and classified IC\/BPS patients, on the basis of cystoscopic findings, as having non\u2010Hunner\u2010type IC and Hunner\u2010type IC. Specimens obtained from the posterior wall in non\u2010Hunner\u2010type IC cases during hydrodistension or from Hunner\/non\u2010Hunner lesions in Hunner\u2010type IC cases during transurethral resection were evaluated. Stress urinary incontinence patients with microscopic haematuria were selected as controls. Biopsy specimens were obtained from 15 non\u2010Hunner\u2010type IC, 15 Hunner\u2010type IC and 5 non\u2010IC patients. Severe and moderate fibrosis was more frequently observed in non\u2010Hunner\u2010type IC than in Hunner\u2010type IC and non\u2010IC cases. However, severe and moderate inflammation was more frequently observed in Hunner\u2010type IC than in non\u2010Hunner\u2010type IC cases. The remnant urothelium was significantly decreased in Hunner\u2010type IC cases as compared with non\u2010Hunner\u2010type IC and non\u2010IC cases (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), and non\u2010Hunner\u2010type IC cases showed a higher number of mast cells than Hunner\u2010type IC and non\u2010IC cases (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.035). Accordingly, several fibrosis\u2010promoting genes were highly expressed in bladder tissues of non\u2010Hunner\u2010type IC, as compared with Hunner\u2010type IC. Patients with severe fibrosis showed significantly higher urinary frequency and smaller bladder capacity than those with moderate and mild fibrosis (all\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010Hunner\u2010type IC is characterized by severe fibrosis and increased mast cell infiltration, whereas Hunner\u2010type IC is characterized by severe inflammation and urothelial denudation in the entire bladder. Fibrosis in the bladder of IC\/BPS patients was correlated with increased urinary frequency and decreased bladder capacity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.13235","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T11:54:54Z","timestamp":1491825294000},"page":"415-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Histopathological characteristics of interstitial cystitis\/bladder pain syndrome without Hunner lesion"],"prefix":"10.1111","volume":"71","author":[{"given":"Aram","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Urology Konkuk University Hospital Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Young","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Urology Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"},{"name":"Department of Biomedical Sciences Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae\u2010Min","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Urology Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"},{"name":"Department of Biomedical Sciences Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan Yeul","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"},{"name":"Department of Biomedical Sciences Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongHwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Un","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Centre University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-2602","authenticated-orcid":false,"given":"Yong Mee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Centre University of Ulsan College of Medicine Seoul 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