{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:03:22Z","timestamp":1793595802145,"version":"4.5.0"},"reference-count":115,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>\n                    Extra\u2010uterine high\u2010grade serous carcinoma (\n                    <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>\n                    ) accounts for most of the morbidity and mortality associated with ovarian carcinoma, and is one of the leading causes of cancer death in women. Until recently our understanding of\n                    <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>\n                    was very limited compared to other common cancers, and it has only been during the last 15 years that we have learned how to diagnose this ovarian carcinoma histotype accurately. Since then, however, there has been rapid progress, with identification of a precursor lesion in the fallopian tube, development of prevention strategies for both those with inherited susceptibility (hereditary breast and ovarian cancer syndrome) and without the syndrome, and elucidation of the molecular events important in oncogenesis. This molecular understanding has led to new treatment strategies for\n                    <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>\n                    , with the promise of more to come in the near future. In this review we focus on these recent changes, including diagnostic criteria\/differential diagnosis, primary site assignment, precursor lesions and the molecular pathology of\n                    <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/his.13248","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T03:02:45Z","timestamp":1494039765000},"page":"339-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["High\u2010grade serous carcinoma of tubo\u2010ovarian origin: recent developments"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-1967","authenticated-orcid":false,"given":"Naveena","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-4370","authenticated-orcid":false,"given":"W Glenn","family":"McCluggage","sequence":"additional","affiliation":[{"name":"Department of Pathology Belfast Health and Social Care Trust Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Blake","family":"Gilks","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Vancouver General Hospital Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.04.017"},{"key":"e_1_2_14_3_1","volume-title":"World Health Organization classification of tumors of the female reproductive organs","author":"World Health Organization","year":"2014"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2016.01.004"},{"key":"e_1_2_14_5_1","volume-title":"Pathology and genetics of tumours of the breast and female genital organs","author":"World Health Organization","year":"2003"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000476"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318164edf7"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181c042b6"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1993.03020072.x"},{"key":"e_1_2_14_10_1","first-page":"354","article-title":"Interpathologist and intrapathologist disagreement in ovarian tumor grading and typing","volume":"8","author":"Baak JP","year":"1986","journal-title":"Anal. 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