{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:58:37Z","timestamp":1782255517094,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["6421"],"award-info":[{"award-number":["6421"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1 checkpoint immunotherapy has been proposed recently as a promising treatment in relapsed\/refractory disease, used eventually in combination with traditional chemotherapy in different cancer settings. To date, no data are available concerning <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1 expression in ampulla of Vater carcinoma and its pre\u2010invasive lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We assessed the immunohistochemical expression of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1 in a series of 26 ampullary adenocarcinomas, 50 ampullary dysplastic lesions and 10 normal duodenal mucosa samples. Moreover, in all cases <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> mismatch repair proteins status was investigated. <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1 was expressed in seven of 26 (26.9%) invasive carcinomas and three of 50 (6.0%) dysplastic samples. Most of the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1\u2010positive tumours (seven of 10) were intestinal\u2010type and poorly differentiated (G3). The number of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1\u2010positive stromal lymphoid cells was significantly higher in dysplastic and invasive lesions than in the normal samples (<jats:italic>P<\/jats:italic> = 0.011). Nineteen dysplastic lesions and eight invasive carcinomas did not show any evident epithelial or stromal <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1 expression. Four of the carcinomas were mismatch repair\u2010deficient and two of these were <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1\u2010positive. Furthermore, mismatch repair\u2010deficient lesions showed a significantly higher average of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1\u2010positive stromal lymphoid cells than those of neoplastic <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1\u2010negative samples (62.8 versus 21.6; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present results suggest a role of the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u2010L1 axis in ampullary adenocarcinomas, and therefore this may also prompt consideration of checkpoint immunotherapy as a novel promising treatment for these tumours.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13254","type":"journal-article","created":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T10:14:05Z","timestamp":1494756845000},"page":"470-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["<scp>PD<\/scp>\u2010L1 overexpression in ampulla of Vater carcinoma and its pre\u2010invasive lesions"],"prefix":"10.1111","volume":"71","author":[{"given":"Deborah","family":"Saraggi","sequence":"first","affiliation":[{"name":"Department of Medicine (DIMED) University of Padua Padua PD Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Galuppini","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED) University of Padua Padua PD Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Remo","sequence":"additional","affiliation":[{"name":"Department of Pathology \u2018Mater 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