{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:43:45Z","timestamp":1772563425665,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T00:00:00Z","timestamp":1501632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Myxomas are benign soft tissue tumours resembling primitive mesenchyme. They rarely involve ocular structures, and have been recognized in the conjunctiva, eyelids, cornea, and orbit. The aim of this study was to investigate the clinicopathological features of seven patients with primary conjunctival myxoma seen at Dr Luis S\u00e1nchez Bulnes Hospital, an ophthalmological referral centre in Mexico City.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We reviewed the clinical, histochemical and immunohistochemical studies of patients with documented myxoma of the conjunctiva diagnosed in our hospital. Seven conjunctival myxomas were retrieved from 5923 conjunctival biopsies (0.1%). The mean age of patients was 40 years, with a range of 27\u201351 years. Females were more frequently affected, and none of our patients had systemic disease. The left eye was involved in five cases, and most of the lesions were located in the bulbar conjunctiva. Histopathological examination revealed a benign tumour composed of spindle\u2010shaped and stellate\u2010shaped cells immersed within an abundant mucinous matrix with sparse vessels and reticulin fibres. Immunohistochemistry demonstrated positivity for vimentin and negativity for smooth muscle actin, <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>10 and <jats:styled-content style=\"fixed-case\">GLUT<\/jats:styled-content>1 in myxoma cells of all cases. S100 was found to be positive in four cases, and muscle\u2010specific\u2010actin in three cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conjunctival myxomas are uncommon tumours. For accurate diagnosis, histopathological examination is mandatory. The treatment of choice is surgical removal, and the prognosis is excellent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13274","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T13:32:46Z","timestamp":1496323966000},"page":"635-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Primary conjunctival myxoma: case series and review of the literature"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3061-9432","authenticated-orcid":false,"given":"Dolores","family":"R\u00edos y Valles\u2010Valles","sequence":"first","affiliation":[{"name":"Ophthalmic Pathology Service Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico IAP, Hospital \u2018Dr Luis S\u00e1nchez Bulnes\u2019 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivette","family":"Hern\u00e1ndez\u2010Ayuso","sequence":"additional","affiliation":[{"name":"Ophthalmic Pathology Service Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico IAP, Hospital \u2018Dr Luis S\u00e1nchez Bulnes\u2019 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor A","family":"Rodr\u00edguez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomopathology and Experimental Medicine \u2018Roberto Ruiz Obreg\u00f3n\u2019 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Medina\u2010Cruz","sequence":"additional","affiliation":[{"name":"Pathology Service Facultad de Medicina UNAM y Hospital General de M\u00e9xico \u2018Dr Eduardo Liceaga\u2019 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Salcedo\u2010Casillas","sequence":"additional","affiliation":[{"name":"Oculoplastics and Orbit Surgery Service Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico IAP, Hospital \u2018Dr Luis S\u00e1nchez Bulnes\u2019 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abelardo A","family":"Rodr\u00edguez\u2010Reyes","sequence":"additional","affiliation":[{"name":"Ophthalmic Pathology Service Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico IAP, Hospital \u2018Dr Luis S\u00e1nchez Bulnes\u2019 Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194804000-00013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64193-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0209"},{"key":"e_1_2_9_5_1","first-page":"709","article-title":"Ocular findings in Carney complex","volume":"1","author":"Chinchurreta\u2010Capote A","year":"2006","journal-title":"Arch. 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