{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:34:02Z","timestamp":1780457642797,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Centre des Ressources Biologiques (CRB)"},{"name":"Hospitalo-Universitaire de Montpellier, France"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Aims<\/jats:title>Distinction between primary cutaneous follicular lymphoma (PCFL<\/jats:styled-content>) and primary cutaneous marginal zone lymphoma (PCMZL<\/jats:styled-content>) is challenging, as clear\u2010cut immunophenotypical and cytogenetic criteria to segregate both entities are lacking.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>To characterize PCFL<\/jats:styled-content> and PCMZL<\/jats:styled-content> more clearly and to define criteria helpful for the differential diagnosis, we compared expression of immunohistochemical markers [LIM<\/jats:styled-content>\u2010only transcription factor 2 (LMO<\/jats:styled-content>2), human germinal centre\u2010associated lymphoma (HGAL<\/jats:styled-content>), stathmin 1 (STMN<\/jats:styled-content>1), activation\u2010induced cytidine deaminase (AID<\/jats:styled-content>), myeloid cell nuclear differentiation antigen (MNDA<\/jats:styled-content>)] and the presence of cytogenetic abnormalities described previously in nodal follicular lymphoma [B cell lymphoma 2 (BCL2<\/jats:italic>) and BCL6<\/jats:italic> breaks, 1p36 chromosomal region deletion (del 1p36)] in a series of 48 cutaneous follicular and marginal zone lymphomas [cutaneous follicular lymphoma (CFL<\/jats:styled-content>) and cutaneous marginal zone lymphoma (CMZL<\/jats:styled-content>)]. Immunostaining for STMN<\/jats:styled-content>1, LMO<\/jats:styled-content>2, HGAL<\/jats:styled-content> and AID<\/jats:styled-content> allowed the distinction between CFL<\/jats:styled-content> and CMZL<\/jats:styled-content>, and STMN<\/jats:styled-content>1 was the most sensitive marker (100% CFL<\/jats:styled-content>, 0% CMZL<\/jats:styled-content>). LMO<\/jats:styled-content>2, HGAL<\/jats:styled-content> and AID<\/jats:styled-content> were positive in 93.2%, 82.1% and 86.2% CFL<\/jats:styled-content> (all CMZL<\/jats:styled-content>\u2010negative). MNDA<\/jats:styled-content> was expressed in both entities without significant difference (10.3% CFL<\/jats:styled-content>, 30.8% CMZL<\/jats:styled-content>, P<\/jats:italic> = 0.18). BCL<\/jats:styled-content>2<\/jats:italic>, BCL<\/jats:styled-content>6<\/jats:italic> breaks and the del 1p36 were present in 16.7%, 10.7% and 18.5% CFL<\/jats:styled-content> and no CMZL<\/jats:styled-content>. Finally, three and 29 CFL<\/jats:styled-content> were reclassified as secondary cutaneous follicular lymphomas (SCFL<\/jats:styled-content>) and PCFL<\/jats:styled-content> without significant differences concerning phenotypical and cytogenetic features. BCL<\/jats:styled-content>2<\/jats:italic>, BCL<\/jats:styled-content>6<\/jats:italic> breaks and the del 1p36 were present in 11.1%, 8% and 16.7% PCFL<\/jats:styled-content> and did not impact the prognosis.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>LMO2, HGAL<\/jats:styled-content>, STMN<\/jats:styled-content>1 and AID<\/jats:styled-content>, but not MNDA<\/jats:styled-content>, are discriminant for the recognition between CFL<\/jats:styled-content> and CMZL<\/jats:styled-content>. BCL<\/jats:styled-content>2<\/jats:italic>, BCL<\/jats:styled-content>6<\/jats:italic> rearrangements and the del 1p36 have a role in the pathogenesis of PCFL<\/jats:styled-content>, the latest being the most common alteration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13279","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T10:12:45Z","timestamp":1496916765000},"page":"648-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Diagnostic value of STMN<\/scp>1, LMO<\/scp>2, HGAL<\/scp>, AID<\/scp> expression and 1p36 chromosomal abnormalities in primary cutaneous B cell lymphomas"],"prefix":"10.1111","volume":"71","author":[{"given":"Evelyne","family":"Verdanet","sequence":"first","affiliation":[{"name":"D\u00e9partement de Biopathologie CHU Montpellier H\u00f4pital Gui De Chauliac Montpellier France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Montpellier 1 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