{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:42:04Z","timestamp":1773074524973,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Samsung Medical Center, Korea","award":["GF01140111"],"award-info":[{"award-number":["GF01140111"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Gastrointestinal stromal tumours (<jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>s) may arise anywhere in the gastrointestinal tract, but are rare in the oesophagus. We describe the clinical, pathological and molecular characteristics of 27 primary oesophageal <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>s, the largest series to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was extracted and exons 9, 11, 13 and 17 of <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic>, exons 12, 14 and 18 of <jats:styled-content style=\"fixed-case\"><jats:italic>PDGFR<\/jats:italic>A<\/jats:styled-content> and exon 15 of <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> were amplified and sequenced. Oesophageal <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>s occurred in 14 men and 13 women aged between 22 and 80\u00a0years (mean: 56\u00a0years). All 27 cases were immunohistochemically positive for <jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content>, and 92 and 47% co\u2010expressed <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34 or smooth muscle actin, respectively. Fifteen (71% of analysed cases) harboured <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> exon 11 mutations and one case each had a mutation in <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> exon 13 (K642E) or <jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> exon 15 (V600E). Long\u2010term follow\u2010up data (median, 96.5\u00a0months) were obtained for 20 cases; two patients had metastases at presentation and seven had developed local recurrence and\/or metastasis after surgery. A large tumour size (\u2265\u00a010\u00a0cm), high mitotic rate (&gt;\u00a05\/5\u00a0mm<jats:sup>2<\/jats:sup>), presence of a deletion mutation in <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> exon 11 involving codons 557\u2013558 and a positive microscopic margin were associated with recurrence and metastasis. The <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> mutations identified in oesophageal <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>s are similar to those observed in gastric <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Complete surgical resection with clear margins is recommended, if technically feasible, and genotyping can help to improve diagnosis and further patient management in oesophageal <jats:styled-content style=\"fixed-case\">GIST<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13292","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T13:26:39Z","timestamp":1498224399000},"page":"805-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Gastrointestinal stromal tumours of the oesophagus: a clinicopathological and molecular analysis of 27 cases"],"prefix":"10.1111","volume":"71","author":[{"given":"Guhyun","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Pathology Sanggye Paik Hospital Inje University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuna","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pathology Dongsan Medical Center Keimyung University Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Yun","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Sanggye Paik Hospital Inje University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mog","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology VA Portland Health Care System and Oregon Health and Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-9205","authenticated-orcid":false,"given":"Kyoung\u2010Mee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L","family":"Corless","sequence":"additional","affiliation":[{"name":"Department of Pathology and Knight Cancer Institute Oregon Health &amp; Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2006.09.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200002000-00007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.05.071"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.01.051"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.01.040"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2012.0017"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.11"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1055-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.123545"},{"key":"e_1_2_7_11_1","first-page":"648","volume-title":"AJCC cancer staging manual","author":"Edge SB","year":"2010"},{"key":"e_1_2_7_12_1","first-page":"417","volume-title":"WHO classification of tumours of the digestive system","author":"Bosman FT","year":"2010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70299-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002446"},{"key":"e_1_2_7_15_1","first-page":"333","article-title":"Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome","volume":"5","author":"Lott S","year":"2015","journal-title":"Am. 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