{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:22:55Z","timestamp":1789456975083,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    The increasing recognition of pituitary disorders and their impact on quality of life and longevity has made understanding of this small gland a subject of paramount importance. Pituitary pathology has seen many significant studies that indicate progress in identification and classification of pituitary lesions, as well as improved management strategies for patients. In this review, we outline six major areas of advances: (i) changes in terminology from \u2018adenoma\u2019 to \u2018pituitary neuroendocrine tumour\u2019; (ii) reclassification of hormone\u2010negative tumours based on transcription factor expression that defines lineage; (iii) updates in new pathogenetic mechanisms, including those that underlie rare lesions such as X\u2010\n                    <jats:styled-content style=\"fixed-case\">LAG<\/jats:styled-content>\n                    and pituitary blastoma; (iv) clarification of hypophysitis due to immunotherapy, xanthomatous hypophysitis due to rupture of a Rathke's cleft cyst and IgG4 disease as the cause of inflammatory pseudotumour; (v) the consolidation of pituicytoma variants, including spindle cell oncocytoma and granular cell tumour based on thyroid transcription factor\u20101 (\n                    <jats:styled-content style=\"fixed-case\">TTF<\/jats:styled-content>\n                    \u20101) reactivity; and (vi) the pathogenetic mechanisms that distinguish papillary from adamantinomatous craniopharyngioma. The remaining challenge is clarification of the pathogenetic mechanisms underlying the development of many of these disorders.\n                  <\/jats:p>","DOI":"10.1111\/his.13295","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T01:41:17Z","timestamp":1513215677000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["What's new in pituitary pathology?"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-5054","authenticated-orcid":false,"given":"Sylvia L","family":"Asa","sequence":"first","affiliation":[{"name":"Department of Pathology Laboratory Medicine Program University Health Network Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Mete","sequence":"additional","affiliation":[{"name":"Department of Pathology Laboratory Medicine Program University Health Network Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036232"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20412"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1668"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03667.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0189"},{"key":"e_1_2_9_7_1","first-page":"2172","article-title":"Epidemiology of pituitary adenoma: results of the first Swiss study","volume":"28","author":"Fontana E","year":"2009","journal-title":"Rev. Med. Suisse"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40478-015-0229-8","article-title":"Histological criteria for atypical pituitary adenomas\u00a0\u2013\u00a0data from the German pituitary adenoma registry suggests modifications","volume":"19","author":"Miermeister CP","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1084-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2014.10.001"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"4","article-title":"Clinical implications of accurate subtyping of pituitary adenomas: perspectives from the treating physician","volume":"31","author":"Gomez\u2010Hernandez K","year":"2015","journal-title":"Turk. Patoloji Derg."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/17446651.2016.1153422"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0004"},{"key":"e_1_2_9_14_1","volume-title":"Tumors of the pituitary gland. Atlas of tumor pathology","author":"Asa SL","year":"1998"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.151"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-6-1111"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913120500323514"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03514.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/347528a0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.5.1275"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","DOI":"10.55418\/9781933477152","volume-title":"Tumors of the pituitary gland. AFIP atlas of tumor pathology","author":"Asa SL","year":"2011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.1.68"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00430697"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.19.2302"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-5-1011"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00282-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9398-z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1385\/EP:16:3:187","article-title":"Double adenomas of the pituitary: transcription factors Pit\u20101, T\u2010pit, and SF\u20101 identify cytogenesis and differentiation","volume":"16","author":"Jastania RA","year":"2005","journal-title":"Endocr. Pathol."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-016-0727-0"},{"key":"e_1_2_9_30_1","first-page":"56","volume-title":"Endocrine pathology","author":"Lyssikatos C","year":"2016"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0944"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(54)90353-8"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.12.e78"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603877103"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2843"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2010.01.001"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-005-0-04-0"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0348"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1013"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-12-0118"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408028"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1285-z"},{"key":"e_1_2_9_43_1","first-page":"315","volume-title":"Endocrine pathology","author":"Asa SL","year":"2016"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/340692a0"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-6-1421"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0998"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3166"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.20"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0689"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4028"},{"key":"e_1_2_9_51_1","first-page":"jc20162261","article-title":"Whole\u2010exome sequencing study of thyrotropin\u2010secreting pituitary adenomas","volume":"17","author":"Sapkota S","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"e_1_2_9_52_1","article-title":"Epigenetics of pituitary tumors: pathogenetic and therapeutic implications","author":"Ezzat S","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"e_1_2_9_53_1","article-title":"Prevalence of hypophysitis in a cohort of patients with metastatic melanoma and prostate cancer treated with ipilimumab","author":"Brilli L","year":"2017","journal-title":"Endocrine"},{"key":"e_1_2_9_54_1","article-title":"Clinical Trial of the Anti\u2010PD\u2010L1 Antibody BMS\u2010936559 in HIV\u20101 infected participants on suppressive antiretroviral therapy","author":"Gay CL","year":"2017","journal-title":"J. Infect. Dis."},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199806000-00011"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9471-x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010051001"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2970"},{"key":"e_1_2_9_59_1","article-title":"Clinical course of pituitary function and image in IgG4\u2010related hypophysitis","author":"Anno T","year":"2017","journal-title":"Endocrinol. Diabetes Metab. Case Rep."},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0642"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00004"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.08.013"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200208000-00010"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31829723e7"},{"key":"e_1_2_9_65_1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s12022-013-9279-2","article-title":"TTF\u20101 expressing sellar neoplasm with ependymal rosettes and oncocytic change: mixed ependymal and oncocytic variant pituicytoma","volume":"25","author":"Kamil Z","year":"2014","journal-title":"Endocr. Pathol."},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1004-x"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-5232-z"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2868"},{"key":"e_1_2_9_69_1","doi-asserted-by":"crossref","first-page":"pii:djv310","DOI":"10.1093\/jnci\/djv310","article-title":"Dramatic response of BRAF V600E mutant papillary craniopharyngioma to targeted therapy","volume":"108","author":"Brastianos PK","year":"2015","journal-title":"J. Natl Cancer Inst."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.13295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:01:53Z","timestamp":1696024913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.13295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/his.13295"],"URL":"https:\/\/doi.org\/10.1111\/his.13295","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]},"assertion":[{"value":"2017-12-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}