{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:35:52Z","timestamp":1774398952331,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Mucinous tubular and spindle cell carcinoma (<jats:styled-content style=\"fixed-case\">MTSC<\/jats:styled-content>) of the kidney is a distinct entity characterized by bland tightly packed elongated tubules and spindle cells with low nucleolar grade in a basophilic mucinous stroma. Several case studies have reported <jats:styled-content style=\"fixed-case\">MTSC<\/jats:styled-content> with high\u2010grade features and have brought into question whether they represented <jats:styled-content style=\"fixed-case\">MTSC<\/jats:styled-content> or a variant of papillary renal cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We searched our pathology database and identified seven cases: six <jats:styled-content style=\"fixed-case\">MTSC<\/jats:styled-content> with high International Society of Urological Pathology (<jats:styled-content style=\"fixed-case\">ISUP<\/jats:styled-content>) nucleolar grade and one <jats:styled-content style=\"fixed-case\">MTSC<\/jats:styled-content> with overall low nucleolar grade but extensive necrosis. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> samples were extracted from paraffin blocks and analysed using a single nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) array platform. Six of seven patients were female, aged between 46 and 82 years. Tumour sizes ranged from 3 to 7.5 cm. One case showed involvement of renal sinus fat and a second case showed involvement of the perinephric fat. All cases shared common chromosomal abnormalities observed with the more typical <jats:styled-content style=\"fixed-case\">MTSC<\/jats:styled-content>, with monosomy of chromosomes 1, 4, 6, 8, 9, 13, 14, 15 and 22. Trisomy of chromosomes 7, 17 and loss of Y chromosome were not observed in any of the cases. None of the patients showed evidence of recurrence or metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The molecular analysis performed in this study supports that <jats:styled-content style=\"fixed-case\">MTSC<\/jats:styled-content> of the kidney can have high nucleolar grade or extensive necrosis, and that they are not papillary renal cell carcinoma. We support modifying the definition of <jats:styled-content style=\"fixed-case\">MTSC<\/jats:styled-content> to include those with higher nucleolar grade.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13298","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T09:07:01Z","timestamp":1498640821000},"page":"719-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Chromosomal abnormalities of high\u2010grade mucinous tubular and spindle cell carcinoma of the kidney"],"prefix":"10.1111","volume":"71","author":[{"given":"Evita T","family":"Sadimin","sequence":"first","affiliation":[{"name":"Department of Pathology Rutgers Cancer Institute of New Jersey New Brunswick NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Bei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-9474","authenticated-orcid":false,"given":"Pedram","family":"Argani","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-6472","authenticated-orcid":false,"given":"Jonathan I","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Pathology, Urology and Oncology Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.24320"},{"key":"e_1_2_7_3_1","volume-title":"World Health Organization classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs","author":"Eble JN","year":"2004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318299f2d1"},{"key":"e_1_2_7_5_1","volume-title":"World Health Organization classification of tumours of the urinary system and male genital organs","author":"Moch H","year":"2016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2006.09.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213271.15221.e3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000180443.94645.50"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800565"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-0036-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31816a1c34"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0267"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-014-0194-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1702-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2014.03.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318031ffff"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2015.04.004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2010.08.003"},{"key":"e_1_2_7_19_1","first-page":"1517","article-title":"Mucinous tubular and spindle cell carcinoma with Fuhrman nuclear grade 3: a histological, immunohistochemical, ultrastructural and FISH study","volume":"23","author":"Kuroda N","year":"2008","journal-title":"Histol. 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