{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:14:48Z","timestamp":1767626088422,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we aimed to investigate the clinicopathological features of CD4<jats:sup>+<\/jats:sup> and\/or CD56<jats:sup>+<\/jats:sup> immature haematolymphoid malignancy (iHLM), including blastic plasmacytoid dendritic cell neoplasm (BPDCN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analysed the clinicopathological features of 46 patients diagnosed consecutively with CD4<jats:sup>+<\/jats:sup>\/CD56<jats:sup>+<\/jats:sup> iHLM. These cases were categorised into three groups based on their immunohistochemical expression of three plasmacytoid dendritic cell (pDC) markers [CD123, CD303 and T cell leukaemia\/lymphoma (TCL1)]: cutaneous BPDCN (<jats:italic>n<\/jats:italic>\u00a0=\u00a035), non\u2010cutaneous BPDCN (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) and non\u2010BPDCN\u2010type CD56<jats:sup>+<\/jats:sup> neoplasms (<jats:italic>n<\/jats:italic>\u00a0=\u00a05). Compared to non\u2010cutaneous BPDCN, cutaneous BPDCN was associated with an older median age at onset (72\u00a0years versus 45\u00a0years, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), and higher positivity for CD4 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), CD123 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) and 2\u20133 pDC markers (89% versus 50%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.05). Cutaneous BPDCN was divided into terminal deoxynucleotidyl transferase (TdT)<jats:sup>+<\/jats:sup> and TdT<jats:sup>\u2212<\/jats:sup> subgroups, which did not differ in prognosis, although TdT<jats:sup>+<\/jats:sup> cases showed a lower median onset age (66\u00a0years versus 79\u00a0years, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) and higher frequency of extracutaneous lesions (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Compared to the BPDCN groups, non\u2010BPDCN\u2010type CD56<jats:sup>+<\/jats:sup> neoplasm cases showed higher cytoplasmic CD3 positivity (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) and less frequent BCL\u20102 expression (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), and lacked cutaneous lesions. However, the survival curves overlapped. Notably, one case involved an unusual composite neoplasm, comprising CD56<jats:sup>+<\/jats:sup> lymphoblastic lymphoma and mature CD56<jats:sup>+<\/jats:sup> cytotoxic T cell lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our present data support the recognition of cutaneous BPDCN as a homogenous entity, in contrast to the non\u2010cutaneous form. Additional research is warranted to characterise non\u2010BPDCN\u2010type CD56<jats:sup>+<\/jats:sup> neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13340","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T08:02:35Z","timestamp":1502352155000},"page":"972-984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinicopathological analysis of 46 cases with CD4<sup>+<\/sup> and\/or CD56<sup>+<\/sup> immature haematolymphoid malignancy: reappraisal of blastic plasmacytoid dendritic cell and related neoplasms"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2288-7162","authenticated-orcid":false,"given":"Yuka","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-3691","authenticated-orcid":false,"given":"Seiichi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Satou","sequence":"additional","affiliation":[{"name":"Department of Pathology Aichi Medical University Hospital Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed E","family":"Eladl","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"},{"name":"Department of Pathology Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-6179","authenticated-orcid":false,"given":"Naoko","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics Nagano Prefectural Suzaka Hospital Suzaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiro","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology Yamagata University Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Taniwaki","sequence":"additional","affiliation":[{"name":"Center for 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