{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:01:56Z","timestamp":1793746916813,"version":"4.6.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dahan Translocation Carcinoma Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"\n Aims<\/jats:title>\n \n We sought to determine if some unclassified renal cell carcinomas (\n RCC<\/jats:styled-content>\n s) in children and young adults that are characterised by predominantly eosinophilic cytoplasm are related to the recently described succinate dehydrogenase (\n SDH<\/jats:styled-content>\n )\u2010deficient\n RCC<\/jats:styled-content>\n , fumarate hydratase (\n FH<\/jats:styled-content>\n )\u2010deficient\n RCC<\/jats:styled-content>\n or eosinophilic solid and cystic (\n ESC<\/jats:styled-content>\n )\n RCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n We reviewed 33 unclassified\n RCC<\/jats:styled-content>\n s with predominantly eosinophilic cytoplasm in patients aged 35\u00a0years or younger. Immunohistochemistry (\n IHC<\/jats:styled-content>\n ) for\n SDHB<\/jats:styled-content>\n ,\n FH<\/jats:styled-content>\n and\n CK<\/jats:styled-content>\n 20 (a marker of\n ESC<\/jats:styled-content>\n ) was performed in all cases.\n IHC<\/jats:styled-content>\n for 2\u2010succinocysteine (2\n SC<\/jats:styled-content>\n ) was performed on\n RCC<\/jats:styled-content>\n with loss of\n FH<\/jats:styled-content>\n labelling. Four\n RCC<\/jats:styled-content>\n (12%) (median age 18\u00a0years) demonstrated loss of\n FH<\/jats:styled-content>\n labelling as well as aberrant 2\n SC<\/jats:styled-content>\n labelling, and were thus classified as\n FH<\/jats:styled-content>\n \u2010deficient\n RCC<\/jats:styled-content>\n s. Importantly, none of these cases demonstrated the characteristic macronucleoli typical of\n FH<\/jats:styled-content>\n \u2010deficient\n RCC<\/jats:styled-content>\n . Eight\n RCC<\/jats:styled-content>\n (24%) (median age 20.5\u00a0years) demonstrated loss of\n SDHB<\/jats:styled-content>\n and were reclassified as\n SDH<\/jats:styled-content>\n \u2010deficient\n RCC<\/jats:styled-content>\n s. Importantly, only four of eight\n SDH<\/jats:styled-content>\n \u2010deficient\n RCC<\/jats:styled-content>\n demonstrated the characteristic cytoplasmic vacuoles and inclusions of typical\n SDH<\/jats:styled-content>\n \u2010deficient\n RCC<\/jats:styled-content>\n . Ten\n RCC<\/jats:styled-content>\n (30%) (median age 27\u00a0years) were reclassified as\n ESC RCC<\/jats:styled-content>\n s. Four of 10\n ESC RCC<\/jats:styled-content>\n were multifocal (one bilateral), four of 10\n ESC RCC<\/jats:styled-content>\n occurred in males and one patient presented with liver and lung metastases, all not described previously in\n ESC<\/jats:styled-content>\n . Eleven\n RCC<\/jats:styled-content>\n (33%) remained unclassified.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Pathologists should have a low threshold for performing\n FH<\/jats:styled-content>\n ,\n SDHB<\/jats:styled-content>\n and\n CK<\/jats:styled-content>\n 20\n IHC<\/jats:styled-content>\n when confronted with unclassified eosinophilic\n RCC<\/jats:styled-content>\n or \u2018oncocytoma\u2019 in young patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.13395","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T12:10:16Z","timestamp":1505218216000},"page":"588-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Re\u2010evaluation of 33 \u2018unclassified\u2019 eosinophilic renal cell carcinomas in young patients"],"prefix":"10.1111","volume":"72","author":[{"given":"Yunjie","family":"Li","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine, Pathology Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E","family":"Reuter","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, Pathology New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-1115","authenticated-orcid":false,"given":"Andres","family":"Matoso","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Pathology Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J","family":"Netto","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Pathology Baltimore MD USA"},{"name":"University of Alabama at Birmingham School of Medicine Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-6472","authenticated-orcid":false,"given":"Jonathan I","family":"Epstein","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Pathology Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-9474","authenticated-orcid":false,"given":"Pedram","family":"Argani","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Pathology Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/era.10.188"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21779"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.072"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.06.104"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22346"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313020310001619901"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199501000-00001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.213"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20839"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000179"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200104000-00002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199907000-00004"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000632"},{"key":"e_1_2_6_16_1","volume-title":"WHO classification of tumours of the urinary system and male genital organs","author":"Moch H","year":"2016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1200\/JCO.2005.04.4693","article-title":"Translocation carcinomas of the kidney after chemotherapy in childhood","volume":"1","author":"Argani P","year":"2006","journal-title":"J. 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