{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:51:55Z","timestamp":1775274715048,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>High\u2010grade serous carcinoma (<jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>) is the most common tubal\/ovarian malignant tumour, and usually presents at an advanced stage. Interval debulking surgery (<jats:styled-content style=\"fixed-case\">IDS<\/jats:styled-content>) after neoadjuvant chemotherapy (<jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content>) is being increasingly used for the management of these patients. The chemotherapy response score (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>) has been proposed for grading the response of tubo\u2010ovarian <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content> on the basis of examination of <jats:styled-content style=\"fixed-case\">IDS<\/jats:styled-content> specimens. Our aims were to evaluate the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> in post\u2010<jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content> cases, assess the interobserver agreement, and correlate it with overall and progression\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> was applied by two independent pathologists on omental and adnexal tumour tissue sections from post\u2010<jats:styled-content style=\"fixed-case\">NACT<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> who had undergone <jats:styled-content style=\"fixed-case\">IDS<\/jats:styled-content>. The assigned primary site of tumour origin was documented. The interobserver agreement and prognostic significance of the <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> were evaluated. There were 103 cases, and in 61.1% of cases a fallopian tubal origin was confirmed. There were 26, 35 and 42 cases with <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>s of 1, 2, and 3, respectively. The interobserver variability for <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> was low (\u03ba = 0.806). The <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> showed a significant correlation with progression\u2010free survival (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> 1 and 2 versus 3: median survival 16 months versus 18 months; <jats:italic>P<\/jats:italic> = 0.004); however, after controlling for debulking status, this association was not significant. The <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> applied to adnexal sections did not show any prognostic significance for either progression\u2010free or overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> is an easy and reproducible method for predicting the prognosis in post\u2010<jats:styled-content style=\"fixed-case\">NACT HGSC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13399","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T14:46:57Z","timestamp":1505486817000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The chemotherapy response score is a useful histological predictor of prognosis in high\u2010grade serous 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Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalini","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynaecological Pathology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranab","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynaecological Pathology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-5353","authenticated-orcid":false,"given":"Rashi","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynaecological Pathology Postgraduate Institute of Medical Education and Research Chandigarh 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