{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:21:23Z","timestamp":1788373283259,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Samsung Medical Center","award":["CRO113031"],"award-info":[{"award-number":["CRO113031"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Aims<\/jats:title>The non\u2010invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC<\/jats:styled-content>) has been managed as a low\u2010risk malignancy. Recently, a proposal was made to reclassify this tumour type as a premalignant lesion and rename it non\u2010invasive follicular thyroid neoplasm with papillary\u2010like nuclear features (NIFTP<\/jats:styled-content>). This study aims to provide the first comprehensive study on molecular genotype\u2013phenotype correlations of encapsulated FVPTC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>This study was performed on 177 consecutive FVPTC<\/jats:styled-content>s from January 2014 to April 2016. These were classified as non\u2010invasive encapsulated FVPTC<\/jats:styled-content> (n<\/jats:italic> = 74) invasive encapsulated FVPTC<\/jats:styled-content> (n<\/jats:italic> = 51), and infiltrative FVPTC<\/jats:styled-content> (n<\/jats:italic> = 52), according to standard criteria, by two independent pathologists. Genetic alterations and other clinicopathological information were compared. BRAF<\/jats:italic>V600E<\/jats:sup> was found in 12.2% (non\u2010invasive) and 11.8% (invasive) of encapsulated FVPTC<\/jats:styled-content>s, and in 34.6% of infiltrative FVPTC<\/jats:styled-content>s (P<\/jats:italic> = 0.001). Mutation in encapsulated FVPTC<\/jats:styled-content>s was limited to cases with rare or abortive papillae. RET<\/jats:styled-content>\u2013PTC<\/jats:styled-content>1<\/jats:italic> and RET<\/jats:styled-content>\u2013PTC<\/jats:styled-content>3<\/jats:italic> rearrangements were present (11.5%) only in infiltrative FVPTC<\/jats:styled-content>s. In contrast, NRAS<\/jats:styled-content><\/jats:italic>, HRAS<\/jats:styled-content><\/jats:italic> and KRAS<\/jats:styled-content><\/jats:italic> mutations were observed more often in encapsulated FVPTC<\/jats:styled-content>s (48.6% in non\u2010invasive and 66.7% in invasive) than in infiltrative FVPTC<\/jats:styled-content>s (15.4%) (P<\/jats:italic> < 0.001). Preoperative cytological examination did not distinguish between non\u2010invasive and invasive encapsulated FVPTC<\/jats:styled-content>s, whereas infiltrative FVPTC<\/jats:styled-content> was more likely to be Bethesda class V\/VI<\/jats:styled-content> than the encapsulated type (60.4% versus 38.1%; P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There were no differences in clinicopathological or molecular profiles between non\u2010invasive and invasive encapsulated FVPTC<\/jats:styled-content>s, except in vascular and capsular invasion. Therefore, the diagnosis of NIFTP<\/jats:styled-content>, like that of follicular adenoma, may require surgical resection and exclusion of those tumours with any papillae.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13401","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T09:26:40Z","timestamp":1505899600000},"page":"648-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Molecular genotyping of the non\u2010invasive encapsulated follicular variant of papillary thyroid carcinoma"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7975-2437","authenticated-orcid":false,"given":"Tae Hyuk","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Endocrinology & Metabolism Department of Medicine Thyroid Centre Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah\u2010Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Ho","family":"Choe","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery Department of Surgery Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery Department of Surgery Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Breast and Endocrine Surgery Department of Surgery Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Yeon","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Radiology Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hee","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Radiology Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Ki","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ik","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Seok","family":"Ki","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Genetics Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sook","family":"Yim","sequence":"additional","affiliation":[{"name":"BioSewoom Inc. 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