{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:08:18Z","timestamp":1788815298583,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Lymphoproliferative disorders (<jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>) characterised by human herpesvirus 8 (<jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>8) and Epstein\u2013Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>) infection are rare and two entities are included in the World Health Organisation classification: primary effusion lymphoma (<jats:styled-content style=\"fixed-case\">PEL<\/jats:styled-content>) and germinotropic <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>. These two entities have very different clinicopathological presentations and prognosis. Here we describe two cases of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>8\u2010positive, <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive lymphoma with clinicopathological features that are not consistent with either <jats:styled-content style=\"fixed-case\">PEL<\/jats:styled-content> or germinotropic <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Both patients were <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative without a history of immunodeficiency. In the first case, the patient presented with localised axillary lymphadenopathy without any other symptoms. Biopsy showed lymphoma cells located predominantly in mantle zones with extension into interfollicular areas. Some follicles showed Castleman features, including lymphocyte\u2010depleted germinal centres penetrated by sclerotic blood vessels and surrounded by concentric rings of small lymphocytes. Using immunohistochemistry, the lymphoma cells were positive for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3 (weak), <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 and <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>8. <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> was positive, as shown by <jats:italic>in\u2010situ<\/jats:italic> hybridisation. The lymphoma cells were negative for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>138, immunoglobulin (Ig)M and kappa and lambda. In the second case, the patient presented with multi\u2010compartmental lymphadenopathy and biopsy showed neoplastic cells that grew in a diffuse pattern with immunoblastic\/plasmablastic morphology. Neoplastic cells were positive for both <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>8 and <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>, partially positive for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>138 and negative for kappa and lambda.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The description of these two cases suggests that the category of <jats:styled-content style=\"fixed-case\">HHV<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content><jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>s is a spectrum, which not only includes <jats:styled-content style=\"fixed-case\">PEL<\/jats:styled-content> and germinotropic <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>, but also other cases that have overlapping but distinctive features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13428","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T15:54:44Z","timestamp":1509724484000},"page":"855-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Lymphoproliferative disorders with concurrent <scp>HHV<\/scp>8 and <scp>EBV<\/scp> infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-4556","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kanagal\u2010Shamanna","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-8006","authenticated-orcid":false,"given":"L Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_2_6_3_1","first-page":"323","volume-title":"WHO classification of tumors of haematopoietic and lymphoid tissues","author":"Said J","year":"2017"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0487"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000434"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800355"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.07.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826731b5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.026542"},{"key":"e_1_2_6_10_1","first-page":"49","article-title":"Unusual immunophenotypic variant of large B\u2010cell lymphoma associated with HHV\u20108 and EBV in an HIV positive patient","volume":"2","author":"Ruiz\u2010Cordero R","year":"2015","journal-title":"Hum. Pathol."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31804d43d8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-012-0156-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2016.09.30"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3124.bloodjournal8883124"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199910)189:2<288::AID-PATH419>3.0.CO;2-F"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515882"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401651"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-010-0092-5"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2014.82"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.233"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701387039"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0975-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.03.003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPULI3W6WUGGPY"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.06.020"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw218"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000823"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.36"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000128"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.13428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T18:29:37Z","timestamp":1695666577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.13428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/his.13428"],"URL":"https:\/\/doi.org\/10.1111\/his.13428","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]},"assertion":[{"value":"2017-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}