{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:28:52Z","timestamp":1791829732830,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>The International Society of Urological Pathology (<jats:styled-content style=\"fixed-case\">ISUP<\/jats:styled-content>) held an expert\u2010driven penile cancer conference in Boston in March 2015, which focused on the new World Health Organisation (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>) classification of penile cancer: human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>)\u2010related tumours and histological grading. The conference was preceded by an online survey of the <jats:styled-content style=\"fixed-case\">ISUP<\/jats:styled-content> members, and the results were used to initiate discussions. Because of the rarity of penile tumours, this was not a consensus but an expert\u2010driven conference aimed at assisting pathologists who do not see these tumours on a regular basis. After a justification for the novel separation of penile squamous cell carcinomas into <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010related and non\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010related\u2010carcinomas, the histological classification of penile carcinoma was proposed; this system was also accepted subsequently by the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> for subtyping of penile carcinomas (2016). A description of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010related neoplasms, which may be recognised by their histological features, was presented, and p16 was recommended as a surrogate indicator of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>. A three\u2010tier grading system was recommended for penile squamous carcinomas; this was also adopted by the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> (2016). Many of the distinctive histological subtypes of squamous cell carcinoma of the penis are associated with distinct grades, based on the squamous cell carcinoma subtype histological features.<\/jats:p>","DOI":"10.1111\/his.13429","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T16:01:35Z","timestamp":1509724895000},"page":"893-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The World Health Organisation 2016 classification of penile carcinomas: a review and update from the International Society of Urological Pathology expert\u2010driven recommendations"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-1429","authenticated-orcid":false,"given":"Antonio L","family":"Cubilla","sequence":"first","affiliation":[{"name":"Instituto de Patolog\u00eda e Investigaci\u00f3n and Facultad de Ciencias M\u00e9dicas Universidad Nacional de Asunci\u00f3n Asunci\u00f3n Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa F","family":"Velazquez","sequence":"additional","affiliation":[{"name":"Miraca Life Sciences and Tufts University Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahul B","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cedars\u2010Sinai Medical Center Los Angeles CA USA"},{"name":"Department of Pathology and Laboratory Medicine University of Tennessee Health Sciences Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-6472","authenticated-orcid":false,"given":"Jonathan","family":"Epstein","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Urology, and Oncology The Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M","family":"Berney","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology Barts Cancer Institute St Bartholomew's Hospital Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy M","family":"Corbishley","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology St George's Healthcare NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Members of the ISUP Penile Tumor Panel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2014.12.017"},{"key":"e_1_2_8_3_1","first-page":"2","volume-title":"World Health Organization classification of tumours of the urinary system and male genital organs","author":"Cubilla AL","year":"2016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","DOI":"10.1097\/00000441-192208000-00015","volume-title":"Neoplastic diseases. 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