{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:38:15Z","timestamp":1784047095205,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Solitary fibrous tumour (<jats:styled-content style=\"fixed-case\">SFT<\/jats:styled-content>) is an uncommon spindle cell neoplasm of fibroblastic origin, first described as a tumour of the pleura and now well established at extrapleural sites. However, <jats:styled-content style=\"fixed-case\">SFT<\/jats:styled-content> in the female genital tract is rare and therefore not fully characterised. Here, we describe a series of 25 <jats:styled-content style=\"fixed-case\">SFT<\/jats:styled-content>s arising throughout the gynaecological tract, including the vulva (14 cases), vagina (one), cervix (one), uterus (six), ovary (two), and fallopian tube (one).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The tumours showed classic histology as well as known variant morphological features, including a fatty component, diffuse stromal hyalinisation, myxoid stroma, and giant\u2010cell angiofibroma\u2010like features. Eleven (11\/25, 44%) were considered to be histologically malignant on the basis of mitotic counts of \u22654 per 10 high\u2010power fields. Follow\u2010up data were available for nine (3\u201356\u00a0months; mean 25\u00a0months). Six patients are alive with no evidence of disease, and three are alive with disease. Both <jats:styled-content style=\"fixed-case\">SFT<\/jats:styled-content> and other spindle cell lesions of the gynaecological tract were stained for <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6. Ninety per cent of <jats:styled-content style=\"fixed-case\">SFT<\/jats:styled-content>s showed nuclear expression of <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6. The majority of other tumour types were negative for <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6, except for a subset of inflammatory myofibroblastic tumours (1\/3; 33%), fibroma\/thecoma (3\/56; 5%), and sclerosing stromal tumour (1\/3; 33%), which showed weak\/focal staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gynaecological <jats:styled-content style=\"fixed-case\">SFT<\/jats:styled-content> can be diagnosed reliably with careful morphological evaluation and judicious use of immunohistochemical stains, and should be considered in the diagnostic workup of spindle cell tumours of unclear lineage in the female genital tract.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13430","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T15:36:38Z","timestamp":1509982598000},"page":"749-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Solitary fibrous tumour of the female genital tract: a clinicopathological analysis of 25 cases"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9896-0365","authenticated-orcid":false,"given":"Eric J","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology Stanford University Medical Center Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke E","family":"Howitt","sequence":"additional","affiliation":[{"name":"Division of Women's &amp; Perinatal Pathology Department of Pathology Harvard Medical School Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D M","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Pathology Harvard Medical School Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa R","family":"Nucci","sequence":"additional","affiliation":[{"name":"Division of Women's &amp; Perinatal Pathology Department of Pathology Harvard Medical School Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"385","article-title":"Primary neoplasms of the pleura: a report of five cases","volume":"11","author":"Klemperer PR","year":"1931","journal-title":"Arch. 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