{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:26:26Z","timestamp":1768317986251,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To further characterise biphasic squamoid renal cell carcinoma (<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>), a recently proposed variant of papillary <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We identified 28 tumours from multiple institutions. They typically showed two cell populations\u2014larger cells with eosinophilic cytoplasm and higher\u2010grade nuclei, surrounded by smaller, amphophilic cells with scanty cytoplasm. The dual morphology was variable (median 72.5% of tumour, range 5\u2013100%); emperipolesis was found in all cases. The male\/female ratio was 2:1, and the median age was 55 years (range 39\u201386 years). The median tumour size was 20 mm (range 9\u201365 mm). Pathological stage <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>1a was found in 21 cases, <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>1b in three, and <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>3a and <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>3b in one each (two not available). Multifocality was found in 32%: multifocal biphasic <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> in one case, biphasic + papillary <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> in two cases, biphasic + clear cell <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> in three cases, biphasic + low\u2010grade urothelial carcinoma of the renal pelvis in one case, and biphasic + Birt\u2013Hogg\u2013Dub\u00e9 syndrome in one case. Positive immunostains included: <jats:styled-content style=\"fixed-case\">PAX<\/jats:styled-content>8, cytokeratin (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>) 7, \u03b1\u2010methylacyl\u2010CoA racemase, epithelial membrane antigen, and vimentin. Cyclin D1 was expressed only in the larger cells. The Ki67 index was higher in the larger cells (median 5% versus \u22641%). Negative stains included: carbonic anhydrase 9, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>117, <jats:styled-content style=\"fixed-case\">GATA<\/jats:styled-content>\u20103, WT1, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>5\/6, and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>20; <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10 and 34\u03b2E12 were variably expressed. Gains of chromosomes 7 and 17 were found in two evaluated cases. Follow\u2010up was available for 23 patients (median 24 months, range 1\u2013244 months): 19 were alive without disease, one was alive with recurrence, and one had died of disease (two had died of other causes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Biphasic papillary <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> is a rare variant of papillary <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>, and is often multifocal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13432","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T01:22:39Z","timestamp":1510190559000},"page":"777-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Biphasic papillary renal cell carcinoma is a rare morphological variant with frequent multifocality: a study of 28 cases"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-8846","authenticated-orcid":false,"given":"Kiril","family":"Trpkov","sequence":"first","affiliation":[{"name":"Calgary Laboratory Services and University of Calgary Rockyview General Hospital Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Athanazio","sequence":"additional","affiliation":[{"name":"Calgary Laboratory Services and University of Calgary Rockyview General Hospital Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Magi\u2010Galluzzi","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Clouston","sequence":"additional","affiliation":[{"name":"Tissupath Melbourne Vic. 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