{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T08:00:01Z","timestamp":1769328001259,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,14]],"date-time":"2018-01-14T00:00:00Z","timestamp":1515888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Grant-in-Aid from Life Fund of Kochi Shimbun and Kochi Broadcast"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Aims<\/jats:title>Stratified mucin\u2010producing intra\u2010epithelial lesion (SMILE<\/jats:styled-content>) and invasive stratified mucin\u2010producing carcinoma (ISMC<\/jats:styled-content>) are recently described cervical and penile lesions. We report an unusual case of mixed variant of penile squamous cell carcinomas with warty, usual and mucoepidermoid SMILE<\/jats:styled-content>\/ISMC<\/jats:styled-content> features.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>A 62\u2010year\u2010old Japanese man had a glans penis lesion of one\u2010and\u2010a\u2010half years\u2019 duration, suggesting malignancy. Partial penectomy and left inguinal lymphadenectomy were performed. Pathological evaluation revealed a mixed squamous cell carcinoma with warty, mucinous and usual features. The mucinous component resembled mucoepidermoid carcinoma (MEC<\/jats:styled-content>) and SMILE<\/jats:styled-content>\/ISMC<\/jats:styled-content>. Glandular differentiation was absent. All the diverse tumour components were negative for p16, which was confirmed by negative human papillomavirus (HPV<\/jats:styled-content>) genotyping. The mucinous component was diffusely positive for cytokeratin 7 and largely negative for cytokeratin 5 and p63. Fluorescence in\u2010situ<\/jats:italic> hybridisation did not detect rearrangement in the MAML<\/jats:styled-content>2<\/jats:italic> or EWSR<\/jats:styled-content>1<\/jats:italic> genes. The tumour was pathological stage pT<\/jats:styled-content>2, pN<\/jats:styled-content>1 (AJCC<\/jats:styled-content> prognostic stage group IIIA<\/jats:styled-content>) and was disease\u2010free 26\u00a0months after surgery.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The lack of glands in the mucinous areas suggested that MEC<\/jats:styled-content> should be separated from adenosquamous carcinoma (ASC<\/jats:styled-content>). Penile SMILE<\/jats:styled-content>\/ISMC<\/jats:styled-content> may occur without dependence upon HPV<\/jats:styled-content> status. Further studies will be necessary to determine the pathogenesis and definition of penile SMILE<\/jats:styled-content>\/ISMC<\/jats:styled-content>, the presence of true MEC<\/jats:styled-content> arising from the glans penis and the clinicopathological differences of penile ASC<\/jats:styled-content>, MEC<\/jats:styled-content> and SMILE<\/jats:styled-content>\/ISMC<\/jats:styled-content>. Herein, we refer to the SMILE<\/jats:styled-content>\u2010like penile lesion as \u2018mucinous penile intra\u2010epithelial neoplasia\u2019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13438","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T16:06:43Z","timestamp":1510848403000},"page":"867-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Penile warty mucoepidermoid carcinoma with features of stratified mucin\u2010producing intra\u2010epithelial lesion and invasive stratified mucin\u2010producing carcinoma"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-0222","authenticated-orcid":false,"given":"Kenji","family":"Yorita","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital Kochi\u2010city Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Japanese Red Cross Kochi Hospital Kochi\u2010city Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takushi","family":"Naroda","sequence":"additional","affiliation":[{"name":"Department of Urology Japanese Red Cross Kochi Hospital Kochi\u2010city Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Urology Japanese Red Cross Kochi Hospital Kochi\u2010city Kochi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Ohe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukul","family":"Divatia","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahul B","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Tennessee Health Sciences Center Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-1429","authenticated-orcid":false,"given":"Antonio L","family":"Cubilla","sequence":"additional","affiliation":[{"name":"Instituto de Patologia e Investigacion Universidad Nacional de Asuncion Asuncion Paraguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitry V","family":"Kazakov","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University Medical Faculty and Charles University Hospital Plzen Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3236-3127","authenticated-orcid":false,"given":"Ondrej","family":"Hes","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University Medical Faculty and Charles University Hospital Plzen Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Michal","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University Medical Faculty and Charles University Hospital Plzen Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Michal","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University Medical Faculty and Charles University Hospital Plzen Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1986.tb05926.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199602000-00003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64746-3"},{"key":"e_1_2_7_5_1","first-page":"262","volume-title":"World Health Organisation classification of tumours of the urinary system and male genital organs","author":"Cubilla AL","year":"2016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1974.tb03748.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5858\/2000-124-0148-MCAITG","article-title":"Mucoepidermoid carcinoma arising in the glans penis","volume":"124","author":"Layfield LJ","year":"2000","journal-title":"Arch. 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