{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:56:36Z","timestamp":1790034996972,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21 CA181923"],"award-info":[{"award-number":["R21 CA181923"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Evidence suggests that up to 70% of high\u2010grade serous ovarian carcinomas (<jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>s) arise potentially from fallopian tube fimbriae, and that many of the remaining cases arise from within the ovary in cortical inclusion cysts (<jats:styled-content style=\"fixed-case\">CIC<\/jats:styled-content>s) with a M\u00fcllerian phenotype (M\u00fcllerian\u2010CICs). It has been proposed that M\u00fcllerian\u2010CICs arise either from metaplasia of mesothelial ovarian surface epithelium (<jats:styled-content style=\"fixed-case\">OSE<\/jats:styled-content>) entrapped within the ovary after ovulation or from normal tubal cells entrapped postovulation. However, this proposal is controversial. We therefore conducted a study of <jats:styled-content style=\"fixed-case\">CIC<\/jats:styled-content>s in women, most of them BRCA1\/2 mutation carriers, undergoing risk\u2010reducing salpingo\u2010oophorectomy at our institution from 2000 to 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We used immunohistochemistry for PAX8, a M\u00fcllerian marker, and calretinin, a mesothelial marker to classify CIC cells. In 499 CICs from 59 women, 72.3% were positive for PAX8 (PAX8<jats:sup>+<\/jats:sup>): \u226510% of CIC cells positive; 43.5% positive for calretinin (calretinin<jats:sup>+<\/jats:sup>). The proportion of PAX8<jats:sup>+<\/jats:sup> CICs increased from 62.9% in premenopausal to 80.5% in postmenopausal patients. The proportion of calretinin<jats:sup>+<\/jats:sup> CICs decreased from 52.6% to 35.6%, respectively. There was significant overlap of PAX8 and calretinin positivity: 82 (16.4%) CICs were PAX8<jats:sup>+<\/jats:sup>\/calretinin<jats:sup>+<\/jats:sup>; 43 (40.2%) of these 82 demonstrated PAX8<jats:sup>+<\/jats:sup>\/calretinin<jats:sup>+<\/jats:sup> in the same cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results, and the increased ratio of PAX8<jats:sup>+<\/jats:sup> to calretinin<jats:sup>+<\/jats:sup> CICs from premenopausal to postmenopausal, show that many PAX8<jats:sup>+<\/jats:sup> CICs probably arise from metaplasia of OSE\u2010derived CICs. The proportion of PAX<jats:sup>+<\/jats:sup>\/calretinin<jats:sup>\u2212<\/jats:sup> CICs arising from OSE\u2010derived CICs is unclear, but our results strongly support the proposal that many M\u00fcllerian\u2010CICs arise from OSE via metaplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13444","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T07:32:43Z","timestamp":1512199963000},"page":"766-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Observations on the origin of ovarian cortical inclusion cysts in women undergoing risk\u2010reducing salpingo\u2010oophorectomy"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-2938","authenticated-orcid":false,"given":"Kay J","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prusha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Linkov","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Jotwani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Kauff","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke University Medical School Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm C","family":"Pike","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181c042b6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.22.2.255"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92335-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213335.40358.47"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf3d79"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.1107"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000180854.28831.77"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00365-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.05.031"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010358"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70308-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e31829b6fbd"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.08.052"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000120"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000201826.46978.e5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33500-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.106"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-016-0482-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.03.017"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822d787c"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182500c4d"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182500c1b"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000935"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e318174f012"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2017.07.022"},{"key":"e_1_2_7_27_1","first-page":"1141","article-title":"Adrenal cyst with both Mullerian and mesothelial differentiation \u2013 a clinicopathological and immunohistochemical study with implications for histogenesis","volume":"32","author":"Koperski L","year":"2017","journal-title":"Histol. 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