{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:15:14Z","timestamp":1791000914366,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 11477"],"award-info":[{"award-number":["IG 11477"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"\n Aims<\/jats:title>\n \n Malignant tumours from the upper aerodigestive tract are grouped collectively in the class of head and neck squamous cell carcinoma (\n HNSCC<\/jats:styled-content>\n ). The head and neck tumours were responsible for more than 500\u00a0000 cancer cases in 2012, accounting for the sixth highest incidence rate and mortality worldwide among all tumour types. Laryngeal squamous cell carcinoma (\n LSCC<\/jats:styled-content>\n ) possesses the second highest incidence rate among all\n HNSCC<\/jats:styled-content>\n . Despite significant advances in surgery and radiotherapy during the last few decades, no treatment has been shown to achieve a satisfactory therapeutic outcome and the mortality rate of\n LSCC<\/jats:styled-content>\n is still high, with a 5\u2010year survival rate of 64%. Therefore, further investigations are required to identify the pathogenesis of\n LSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n In order to search for new\n LSCC<\/jats:styled-content>\n biomarkers, we have analysed the expression of the\n HMGA<\/jats:styled-content>\n family members,\n \n HMGA<\/jats:styled-content>\n 1\n <\/jats:italic>\n and\n \n HMGA<\/jats:styled-content>\n 2\n <\/jats:italic>\n , by quantitative reverse transcription\u2013polymerase chain reaction (\n qRT<\/jats:styled-content>\n \u2013\n PCR<\/jats:styled-content>\n ) and immunohistochemistry.\n HMGA<\/jats:styled-content>\n proteins are usually absent in the healthy adult tissues. In contrast, their constitutive expression is a feature of several neoplasias, being associated with a highly malignant phenotype and reduced survival. Here, we report\n \n HMGA<\/jats:styled-content>\n 2\n <\/jats:italic>\n overexpression in larynx carcinomas. Conversely,\n \n HMGA<\/jats:styled-content>\n 1\n <\/jats:italic>\n does not show any differences in its expression between normal and carcinoma tissues. Interestingly,\n \n HMGA<\/jats:styled-content>\n 2\n <\/jats:italic>\n overexpression appears associated with that of two\n \n HMGA<\/jats:styled-content>\n 1\n <\/jats:italic>\n \u2010pseudogenes,\n \n HMGA<\/jats:styled-content>\n 1P6\n <\/jats:italic>\n and\n \n HMGA<\/jats:styled-content>\n 1P7\n <\/jats:italic>\n , acting as a sponge for\n HMGA<\/jats:styled-content>\n 1\u2010 and\n HMGA<\/jats:styled-content>\n 2\u2010targeting micro\n RNA<\/jats:styled-content>\n s and involved in several human cancers.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Therefore,\n HMGA<\/jats:styled-content>\n 2 overexpression appears to be a strong feature of larynx carcinoma, supporting its detection as a valid tool for the diagnosis of these malignancies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.13456","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T13:43:41Z","timestamp":1513950221000},"page":"1102-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["HMGA<\/scp>\n 2, but not\n HMGA<\/scp>\n 1, is overexpressed in human larynx carcinomas"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7977-8522","authenticated-orcid":false,"suffix":"Jr","given":"Antonio","family":"Palumbo","sequence":"first","affiliation":[{"name":"Programa de Carcinog\u00eanese Molecular Instituto Nacional de C\u00e2ncer \u2013 INCA Rio de Janeiro Brazil"},{"name":"Laborat\u00f3rio de Intera\u00e7\u00f5es Celulares Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"De Martino","sequence":"additional","affiliation":[{"name":"Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c\/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche Scuola di Medicina e Chirurgia di Napoli Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Esposito","sequence":"additional","affiliation":[{"name":"Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c\/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche Scuola di Medicina e Chirurgia di Napoli Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Fraggetta","sequence":"additional","affiliation":[{"name":"Department of Pathology Ospedale Cannizzaro Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro N","family":"Neto","sequence":"additional","affiliation":[{"name":"Programa de Carcinog\u00eanese Molecular Instituto Nacional de C\u00e2ncer \u2013 INCA Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Valverde Fernandes","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Patologia Instituto Nacional de C\u00e2ncer \u2013 INCA Rua Cordeiro da Gra\u00e7a Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella C","family":"Santos","sequence":"additional","affiliation":[{"name":"Se\u00e7\u00e3o de Cirurgia de Cabe\u00e7a e Pesco\u00e7o Instituto Nacional de C\u00e2ncer \u2013 INCA Pra\u00e7a da Cruz Vermelha Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando L","family":"Dias","sequence":"additional","affiliation":[{"name":"Se\u00e7\u00e3o de Cirurgia de Cabe\u00e7a e Pesco\u00e7o Instituto Nacional de C\u00e2ncer \u2013 INCA Pra\u00e7a da Cruz Vermelha Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz E","family":"Nasciutti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Intera\u00e7\u00f5es Celulares Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Meireles Da Costa","sequence":"additional","affiliation":[{"name":"Programa de Carcinog\u00eanese Molecular Instituto Nacional de C\u00e2ncer \u2013 INCA Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Fusco","sequence":"additional","affiliation":[{"name":"Programa de Carcinog\u00eanese Molecular Instituto Nacional de C\u00e2ncer \u2013 INCA Rio de Janeiro Brazil"},{"name":"Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c\/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche Scuola di Medicina e Chirurgia di Napoli Universit\u00e0 degli Studi di Napoli \u2018Federico II\u2019 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Felipe","family":"Ribeiro Pinto","sequence":"additional","affiliation":[{"name":"Programa de Carcinog\u00eanese Molecular Instituto Nacional de C\u00e2ncer \u2013 INCA Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11265"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2982"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000156171.70521.dc"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1367::AID-CNCR21>3.0.CO;2-3"},{"key":"e_1_2_8_6_1","first-page":"4993","article-title":"Pharyngeal and cervical cancer incidences significantly correlate with personal UV doses among whites in the United States","volume":"34","author":"Godar DE","year":"2014","journal-title":"Anticancer Res."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199805)20:3<250::AID-HED11>3.0.CO;2-O"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.07.016"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.007641"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.03.013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0944"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0664-2"},{"key":"e_1_2_8_13_1","first-page":"799","article-title":"The better performance status, the better outcome: laryngeal carcinoma treated with definitive radiotherapy","volume":"37","author":"Yurut\u2010Caloglu V","year":"2008","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.5.2114"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(94)90232-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90554-P"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/376771a0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2271"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3482"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.557"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3068"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"8341","DOI":"10.18632\/oncotarget.2202","article-title":"HMGA1 pseudogenes as candidate proto\u2010oncogenic competitive endogenous RNAs","volume":"30","author":"Esposito F","year":"2014","journal-title":"Oncotarget"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.4161\/15384101.2014.974440"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1021520"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7427"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-015-0014-8"},{"key":"e_1_2_8_28_1","first-page":"1896","article-title":"Human colorectal carcinomas express high levels of high mobility group HMGI (Y) proteins","volume":"56","author":"Fedele M","year":"1996","journal-title":"Cancer Res."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601391"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2542"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0291"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8288"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-03-0151"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37622"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217982109"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4133"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200512110"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1215388"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.10.014"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.13456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:31:10Z","timestamp":1695497470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.13456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/his.13456"],"URL":"https:\/\/doi.org\/10.1111\/his.13456","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]},"assertion":[{"value":"2017-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}