{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:02:24Z","timestamp":1778878944991,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ck0106015h0002"],"award-info":[{"award-number":["15ck0106015h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26460446"],"award-info":[{"award-number":["JP26460446"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K19093"],"award-info":[{"award-number":["JP16K19093"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005968","name":"Leukemia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Adult T cell leukaemia\/lymphoma (ATLL) is an aggressive malignancy with a poor prognosis. Human leucocyte antigen (HLA) and \u03b22 microglobulin (\u03b22M) serve as key molecules in tumour immunity, and their expression is reduced frequently in tumour cells. Programmed cell death (PD)\u20101\/PD\u2010ligand1 (PD\u2010L1) interactions play a role in escape of tumour cells from T cell immunity. Therefore, this study aimed to determine the clinicopathological relevance of HLA and \u03b22M expressions in ATLL cells and PD\u2010L1 expression in lymphoma or stromal cells and predict the overall survival of patients with ATLL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analysed a total of 123 biopsy samples from patients newly diagnosed with ATLL by using immunohistochemical analysis. Of the patients enrolled, 91 (74%) were positive for HLA (in cell membrane, 60 patients), 89 (72%) were positive for \u03b22M (in cell membrane, 54 patients) and 48 (39%) were positive for both HLA and \u03b22M in the cell membrane (HLA<jats:sup>m+<\/jats:sup>\u03b22M<jats:sup>m+<\/jats:sup>). No significant clinical differences other than prognosis were found between the HLA<jats:sup>m+<\/jats:sup>\u03b22M<jats:sup>m+<\/jats:sup> group and the other groups. Immunophenotypical evaluation revealed significantly higher rates of CD30\u2010positive lymphoma cells (<jats:italic>P<\/jats:italic> = 0.003) and PD\u2010L1\u2010positive stromal cells in microenvironments (miPD\u2010L1<jats:sup>high<\/jats:sup>) (<jats:italic>P<\/jats:italic> = 0.011) of the HLA<jats:sup>m+<\/jats:sup>\u03b22M<jats:sup>m+<\/jats:sup> group than in the other groups. The HLA<jats:sup>m+<\/jats:sup>\u03b22M<jats:sup>m+<\/jats:sup> group had a significantly better prognosis that the other groups (<jats:italic>P<\/jats:italic> = 0.0096), and patients showing HLA<jats:sup>m+<\/jats:sup>\u03b22M<jats:sup>m+<\/jats:sup> with miPD\u2010L1<jats:sup>high<\/jats:sup> had the most favourable prognosis among all groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The membranous expression of HLA and \u03b22M is likely to reflect the immune response and would be useful to predict prognosis before starting ATLL therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13461","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T11:37:13Z","timestamp":1514979433000},"page":"945-954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Expression pattern of immunosurveillance\u2010related antigen in adult T cell 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