{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:18:09Z","timestamp":1790050689181,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V106C-037"],"award-info":[{"award-number":["V106C-037"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Aggressive natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>)\u2010cell leukaemia (<jats:styled-content style=\"fixed-case\">ANKCL<\/jats:styled-content>) and extranodal <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">ENKTCL<\/jats:styled-content>) with secondary bone marrow involvement are rare bone marrow <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T\u2010cell neoplasms and share similar features. This study aimed to distinguish these two entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We studied bone marrow <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T\u2010cell neoplasms by classifying them into those with no extramedullary mass (group 1, eight cases) and those with extramedullary mass (group 2, 13 cases). The two groups showed similar clinical presentations and pathological features. Fever and cytopenia were the most common clinical presentations in both groups. The neoplastic cells varied from small and relatively monotonous cells to large pleomorphic cells. In six cases (two in group 1, and four in group 2), the neoplastic infiltrate was inconspicuous, consisting of \u226410% of marrow cells in the interstitium, which were hardly identified by haematoxylin and eosin staining alone. Nearly all patients rapidly died, regardless of the neoplastic infiltrate volume. All of the group 1 patients fulfilled the World Health Organisation 2017 diagnostic criteria of <jats:styled-content style=\"fixed-case\">ANKCL<\/jats:styled-content>, and their survival was significantly worse than that of the group 2 patients (<jats:italic>P<\/jats:italic> = 0.035). In addition, there was a significant association between being in group 1 and chromosome 7 abnormalities. Chromosome 6q deletion, which is commonly reported in <jats:styled-content style=\"fixed-case\">ENKTCL<\/jats:styled-content>, was seen in two of our group 2 patients, and was not observed in any of our group 1 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ANKCL<\/jats:styled-content> with no extramedullary mass should be distinguished from <jats:styled-content style=\"fixed-case\">ENKTCL<\/jats:styled-content> with bone marrow involvement, as the former shows distinct outcomes and genetic features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13463","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T07:26:59Z","timestamp":1515050819000},"page":"955-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Aggressive natural killer (<scp>NK<\/scp>)\u2010cell leukaemia and extranodal <scp>NK<\/scp>\/T\u2010cell lymphoma are two distinct diseases that differ in their clinical presentation and cytogenetic findings"],"prefix":"10.1111","volume":"72","author":[{"given":"Ching\u2010Fen","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-4291","authenticated-orcid":false,"given":"Chih\u2010Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"College of Nursing National Taipei University of Nursing and Health Sciences Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M\u2010T","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Pathology and Laboratory Medicine Cheng Hsin General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"World Health Organization classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130984"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826731b5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp418"},{"key":"e_1_2_8_6_1","first-page":"6403","article-title":"Systemic lymphoma arising from hydroa vacciniforme\u2010like lymphoma: report of two cases with review of literature","volume":"7","author":"Yang YQ","year":"2014","journal-title":"Int. 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