{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T05:38:08Z","timestamp":1775367488148,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the present study was to compare treated lymphoma\u2010associated Epstein\u2013Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>)\u2010positive mucocutaneous ulcer (<jats:styled-content style=\"fixed-case\">EBVMCU<\/jats:styled-content>) and methotrexate (<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>)\u2010associated <jats:styled-content style=\"fixed-case\">EBVMCU<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Of a series of 15 Japanese patients (11 women, four men; median age 74\u00a0years, range 35\u201384\u00a0years), seven received <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content> for the treatment of autoimmune disease and eight developed <jats:styled-content style=\"fixed-case\">EBVMCU<\/jats:styled-content> after treatment of malignant lymphoma [diffuse large B\u2010cell lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) without <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> association, adult T\u2010cell leukaemia\/lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), angioimmunoblastic T\u2010cell lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01), and follicular lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01)]. Ulcers were observed in the oral cavity (<jats:italic>n<\/jats:italic>\u00a0=\u00a011), gastrointestinal tract (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), and skin (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). All were histologically characterised by a mixture of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive large B\u2010cell proliferation and Hodgkin\/Reed\u2013Sternberg\u2010like cells on a polymorphous background. A total of 46% (6\/13) had monoclonal immunoglobulin heavy chain gene rearrangement, but none had clonal T\u2010cell receptor gene rearrangement. Spontaneous regression occurred in 13 of 15 cases (87%); the other two cases (13%) achieved complete remission after treatment. Of two patients in the treated lymphoma\u2010associated subgroup, one developed multiple new ulcerative lesions on previously unaffected skin, and the other had a relapse of <jats:styled-content style=\"fixed-case\">EBVMCU<\/jats:styled-content> in the oral cavity. No significant clinicopathological differences were found between the subgroups. Notably, none of the patients died from <jats:styled-content style=\"fixed-case\">EBVMCU<\/jats:styled-content>. However, the treated lymphoma\u2010associated subgroup had lower overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) and a shorter follow\u2010up period (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) than the <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>\u2010associated subgroup, owing to death from non\u2010associated causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treated lymphoma\u2010associated <jats:styled-content style=\"fixed-case\">EBVMCU<\/jats:styled-content>, which is an indolent and self\u2010limited condition, must be recognised to avoid misdiagnosing it as a relapse of malignant lymphoma during treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13464","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T14:55:46Z","timestamp":1515077746000},"page":"1115-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Comparison of Epstein\u2013Barr virus\u2010positive mucocutaneous ulcer associated with treated lymphoma or methotrexate in Japan"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-218X","authenticated-orcid":false,"given":"Teerada","family":"Daroontum","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"},{"name":"Department of Pathology Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of 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