{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:27:08Z","timestamp":1789043228163,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001282","name":"Institute of Child Health, University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Lumbosacral lipomas (<jats:styled-content style=\"fixed-case\">LSL<\/jats:styled-content>) are congenital disorders of the terminal spinal cord region that have the potential to cause significant spinal cord dysfunction in children. They are of unknown embryogenesis with variable clinical presentation and natural history. It is unclear whether the spinal cord dysfunction reflects a primary developmental dysplasia or whether it occurs secondarily to mechanical traction (spinal cord tethering) with growth. While different anatomical subtypes are recognised and classified according to radiological criteria, these subtypes correlate poorly with clinical prognosis. We have undertaken an analysis of surgical specimens in order to describe the spectrum of histological changes that occur and have correlated the histology with the anatomical type of <jats:styled-content style=\"fixed-case\">LSL<\/jats:styled-content> to determine if there are distinct histological subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The histopathology was reviewed of 64 patients who had undergone surgical resection of <jats:styled-content style=\"fixed-case\">LSL<\/jats:styled-content>. The presence of additional tissues and cell types were recorded. <jats:styled-content style=\"fixed-case\">LSL<\/jats:styled-content>s were classified from pre\u2010operative magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) scans according to Chapman classification. Ninety\u2010five per cent of the specimens consisted predominantly of mature adipocytes with all containing thickened bands of connective tissue and peripheral nerve fibres, 91% of samples contained ectatic blood vessels with thickened walls, while 22% contained central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) glial tissue. Additional tissue was identified of both mesodermal and neuroectodermal origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our analysis highlights the heterogeneity of tissue types within all samples, not reflected in the nomenclature. The diversity of tissue types, consistent across all subtypes, challenges currently held notions regarding the embryogenesis of <jats:styled-content style=\"fixed-case\">LSL<\/jats:styled-content>s and the assumption that clinical deterioration is due simply to tethering.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13469","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T16:18:39Z","timestamp":1516378719000},"page":"1136-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The pathology of lumbosacral lipomas: macroscopic and microscopic disparity have implications for embryogenesis and mode of clinical deterioration"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-7865","authenticated-orcid":false,"given":"Victoria","family":"Jones","sequence":"first","affiliation":[{"name":"Developmental Biology and Cancer Programme UCL Institute of Child Health London UK"},{"name":"Department of Neurosurgery Great Ormond Street Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Wykes","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Great Ormond Street Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicki","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Histopathology Great Ormond Street Hospital NHS Trust London UK"},{"name":"Department of Histopathology Kings College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Great Ormond Street Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom S","family":"Jacques","sequence":"additional","affiliation":[{"name":"Developmental Biology and Cancer Programme UCL Institute of Child Health London UK"},{"name":"Department of Histopathology Great Ormond Street Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC-07\/08\/E10"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-012-1775-z"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000114923.76542.81"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.30.2.174"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.ra.2014-0442"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-013-2187-4"},{"key":"e_1_2_7_8_1","first-page":"37","article-title":"Congenital intraspinal lipomas: anatomic considerations and surgical treatment","volume":"9","author":"Chapman 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