{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:06:36Z","timestamp":1769015196487,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010125","name":"Jalmari ja Rauha Ahokkaan S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007083","name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Aims<\/jats:title>Oral tongue squamous cell carcinoma (OTSCC<\/jats:styled-content>) has a relatively poor outcome, and there is a need to identify better prognostic factors. Recently, tumour\u2013stroma ratio (TSR<\/jats:styled-content>) has been associated with prognosis in several cancers. The aim of this multi\u2010institutional study was to evaluate the prognostic value of TSR<\/jats:styled-content> from original haematoxylin and eosin (HE<\/jats:styled-content>)\u2010stained tumour\u2010resection slides in a series of early\u2010stage (cT<\/jats:styled-content>1\u20102N0) OTSCC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>A TSR<\/jats:styled-content> cutoff value of 50% was used to divide the patients into stroma\u2010rich (\u226550%) and stroma\u2010poor (<50%) groups. The relationships between TSR<\/jats:styled-content> and clinicopathological characteristics of 311 early\u2010stage OTSCC<\/jats:styled-content> cases were analysed. The prognostic value of TSR<\/jats:styled-content> in OTSCC<\/jats:styled-content> was calculated separately and in combination with a previously published cancer cell budding and depth of invasion (BD<\/jats:styled-content>) prognostic model. A total of 89 cases (28.6%) belonged to the stroma\u2010rich group. In a multivariate analysis, the stroma\u2010rich group had worse disease\u2010free survival, with a hazard ratio (HR<\/jats:styled-content>) of 1.81 [95% confidence interval (CI<\/jats:styled-content>) 1.17\u20132.79, P<\/jats:italic> = 0.008], and higher cancer\u2010related mortality (HR<\/jats:styled-content> 1.71, 95% CI<\/jats:styled-content> 1.02\u20132.86, P<\/jats:italic> = 0.03). The combination of the highest\u2010risk parameter scores of TSR<\/jats:styled-content> and the BD<\/jats:styled-content> model showed significant correlations with recurrence rate (HR<\/jats:styled-content> 3.42, 95% CI<\/jats:styled-content> 1.71\u20136.82, P<\/jats:italic> = 0.004) and cancer\u2010related mortality (HR<\/jats:styled-content> 11.63, 95% CI<\/jats:styled-content> 3.83\u201335.31, P<\/jats:italic> < 0.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We conclude that TSR<\/jats:styled-content> is a simple histopathological feature that is useful for prognostication of early\u2010stage OTSCC<\/jats:styled-content>, and suggest that TSR<\/jats:styled-content> analyses in association with BD<\/jats:styled-content> score could be included in routine clinical pathology reports for HE<\/jats:styled-content>\u2010stained slides.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13481","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T09:56:44Z","timestamp":1518256604000},"page":"1128-1135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Prognostic impact of tumour\u2013stroma ratio in early\u2010stage oral tongue cancers"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4106-314X","authenticated-orcid":false,"given":"Alhadi","family":"Almangush","sequence":"first","affiliation":[{"name":"Department of Pathology University of Helsinki Helsinki Finland"},{"name":"Department of Pathology University of Turku Turku Finland"},{"name":"Institute of Dentistry University of Misurata Misurata Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Heikkinen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki Helsinki Finland"},{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nassira","family":"Bakhti","sequence":"additional","affiliation":[{"name":"Master of Biostatistics Department of Statistics Faculty of Sciences Hasselt University Hasselt Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K","family":"M\u00e4kinen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joonas H","family":"Kauppila","sequence":"additional","affiliation":[{"name":"Cancer and Translational Medicine Research Unit Medical Research Centre Oulu University of Oulu and Oulu University Hospital Oulu Finland"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Pukkila","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaana","family":"Hagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Helsinki Helsinki Finland"},{"name":"HUSLAB Department of Pathology Helsinki University Hospital Helsinki Finland"},{"name":"Research Programmes Unit Translational Cancer Biology University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jussi","family":"Laranne","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Tampere University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ylermi","family":"Soini","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz P","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Otorhinolaryngology A. 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Camargo Cancer Centre S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reidar","family":"Gr\u00e9nman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Turku University Hospital University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caj","family":"Haglund","sequence":"additional","affiliation":[{"name":"Research Programmes Unit Translational Cancer Biology University of Helsinki Helsinki Finland"},{"name":"Department of Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti A","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Helsinki University Hospital and University of Helsinki Helsinki Finland"},{"name":"Division of Ear, Nose and Throat Diseases Department of 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