{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T21:49:40Z","timestamp":1785102580110,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To confirm whether or not grade 4 asbestosis progresses from the respiratory bronchiole to the peripheral lung.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We examined retrospectively the autopsy or lobectomy specimens from 31 cases (29 males; mean age 64 years) satisfying the pathological criteria of grade 4 asbestosis. Asbestos bodies (<jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>s) were quantified in samples of dissolved lung and in tissue preparations on glass slides. Respiratory bronchiolar lesions were graded as 0, 1 and \u22652. Grade 4 asbestosis was subdivided into an atelectatic induration (<jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content>) and usual interstitial pneumonia pattern (<jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> pattern). Five, 10, and 16 cases had grades 0, 1 or \u22652 lesions, respectively, with mean respective numbers of <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>s in dissolved lung of 117 000\/g dry lung, 468 000\/g and 968 000\/g; and in specimens on glass slides of seven <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>s\/cm<jats:sup>2<\/jats:sup> of tissue slice, 34 <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>s \/cm<jats:sup>2<\/jats:sup> and 195 <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>s \/cm<jats:sup>2<\/jats:sup>. The differences were significant. Fifteen and 16 cases showed <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> patterns, respectively, with mean respective numbers of <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>s in dissolved lung of 1 006 000\/g dry lung and 354 000\/g, and 186 and 56 <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>s\/cm<jats:sup>2<\/jats:sup> on glass slides. The differences were significant. <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> patterns originated in subpleural lobules or subpleural zonal areas and <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> patterns originated in subpleural, peripheral lobules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Grade 4 asbestosis does not start in the respiratory bronchiole. The presence of a grade 1 lesion is not required for the diagnosis of grade 4 asbestosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13493","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:21:08Z","timestamp":1519244468000},"page":"29-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Grade 4 asbestosis does not extend directly from the respiratory bronchiole to the peripheral lung"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-5341","authenticated-orcid":false,"given":"Yoshinori","family":"Kawabata","sequence":"first","affiliation":[{"name":"Division of Diagnostic Pathology Saitama Prefectural Cardiovascular and Respiratory Centre Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Kinki\u2010chuo Chest Medical Centre Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Kobashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Tenri Hospital Tanri City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunimitsu","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka Habikino Medical Centre Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimasa","family":"Uekusa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kanto Rousai Hospital Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Kurashima","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Saitama Prefectural Cardiovascular and Respiratory Centre Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Saitama Prefectural Cardiovascular and Respiratory Centre Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Asbestos: elimination of asbestos\u2010related diseases","author":"World Health Organisation (WHO)","year":"2010"},{"key":"e_1_2_7_3_1","first-page":"544","article-title":"The pathology of asbestos associated diseases of the lungs and pleural cavities: diagnostic criteria and proposed grading schema (Report of the Pneumoconiosis Committee of the College of American Pathologists and the National Institute for Occupational Safety and Health)","volume":"106","author":"Craighead JE","year":"1982","journal-title":"Arch. 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