{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:19:02Z","timestamp":1785525542848,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Pathological differential diagnoses of pleuroparenchymal fibroelastosis (<jats:styled-content style=\"fixed-case\">PPFE<\/jats:styled-content>) include usual interstitial pneumonia (<jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content>) and pulmonary apical cap (<jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>); however, there are no specific immunostaining makers to distinguish between these diseases. We performed immunohistochemistry using several pleural mesothelial cell\u2010related markers, including cytokeratin\u20105\/6, CAM5.2, <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>\u20101, calretinin, desmin and podoplanin, for <jats:styled-content style=\"fixed-case\">PPFE<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 4), <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 10) and <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 3) lung sections. Among the examined markers, in <jats:styled-content style=\"fixed-case\">PPFE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content> lungs podoplanin commonly showed positivity for spindle cells both in thickened pleura and subpleural fibroelastosis lesions; these cells were also stained with \u03b1\u2010smooth muscle actin, a marker of myofibroblasts. However, even in elastic fibre\u2010rich cases, <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> lungs did not show such podoplanin\u2010positive myofibroblasts in pleura\/subpleura and fibroblastic foci. These findings were also verified using immunofluorescence. By contrast, immunohistochemically as well as morphologically, the difference between <jats:styled-content style=\"fixed-case\">PPFE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content> was not apparent. The presence of podoplanin\u2010positive myofibroblasts could be a pathological hallmark of <jats:styled-content style=\"fixed-case\">PPFE<\/jats:styled-content>, suggesting a pathogenic process distinct from <jats:styled-content style=\"fixed-case\">UIP<\/jats:styled-content> but common to <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/his.13494","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T07:26:40Z","timestamp":1519284400000},"page":"1209-1215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Podoplanin\u2010positive myofibroblasts: a pathological hallmark of pleuroparenchymal fibroelastosis"],"prefix":"10.1111","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-4268","authenticated-orcid":false,"given":"Yasunori","family":"Enomoto","sequence":"first","affiliation":[{"name":"Department of Regenerative 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