{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:35:06Z","timestamp":1783496106908,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Aims<\/jats:title>The currently recognised subtypes of anal canal\/peri\u2010anal adenocarcinoma are those arising from low rectal mucosa or columnar cuff, fistula\u2010related tumours and anal gland carcinoma. This report presents two examples of a hitherto undescribed subtype of peri\u2010anal adenocarcinoma with an intestinal phenotype.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>A 74\u2010year\u2010old man had a peri\u2010anal tumour locally excised, whereas a 73\u2010year\u2010old female underwent an abdominoperineal resection for peri\u2010anal Paget's disease with an underlying carcinoma. Neither patient had a history of perineal fistulae, Crohn's disease or previous gastrointestinal neoplasia, and neither showed clinical, radiological or endoscopic evidence of another abdominal or pelvic tumour. Both resection specimens contained adenocarcinoma, which were similar in demonstrating an intestinal morphology and CDX<\/jats:styled-content>2 immunopositivity. The man has shown a disease\u2010free outcome thus far, but the woman has suffered with nodal and pelvic recurrence within a few months of surgery.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The name \u2018primary peri\u2010anal adenocarcinoma of intestinal type\u2019 is proposed for this previously unrecognised subtype of perineal neoplasia. Awareness of its distinct existence \u2013 by recognising its intestinal morphology and immunophenotype while excluding metastasis from the intestinal tract \u2013 should help to collate data to determine its specific prognosis and to formulate its best management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13495","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:20:46Z","timestamp":1519244446000},"page":"157-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary peri\u2010anal adenocarcinoma of intestinal type \u2013 a new proposed entity"],"prefix":"10.1111","volume":"73","author":[{"given":"Pelvender S","family":"Gill","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Southmead Hospital Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9537-4106","authenticated-orcid":false,"given":"Newton A C S","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Southmead Hospital Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"183","volume-title":"WHO classification of tumours of the digestive system","author":"Welton ML","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237388"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1984.tb02342.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.5858\/2007-131-1304-ICOAGC","article-title":"Immunophenotypic characterization of anal gland carcinoma: loss of p63 and cytokeratin 5\/6","volume":"131","author":"Lisovsky M","year":"2007","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.04.019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-1970-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820808"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018805"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2016.11929414"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000159104.02985.6b"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPVZ0QNLUO7OFE"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000157"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.13495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:37:18Z","timestamp":1695472638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.13495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,25]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/his.13495"],"URL":"https:\/\/doi.org\/10.1111\/his.13495","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,25]]},"assertion":[{"value":"2017-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}