{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:29Z","timestamp":1740126149430,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["R015931012"],"award-info":[{"award-number":["R015931012"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Aims<\/jats:title>Interobserver reliability of histopathological features in differentiation between cutaneous polyarteritis nodosa (cPAN<\/jats:styled-content>) and superficial thrombophlebitis (ST<\/jats:styled-content>) by assessment of inter\u2010rater agreement of five histological features was investigated.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>All sections of cPAN<\/jats:styled-content> and ST<\/jats:styled-content> were evaluated independently by three experienced pathologists and one resident of pathology. The histopathological features studied included elastic fibre distribution in the vascular wall, a smooth muscle arrangement pattern, an internal elastic lamina pattern, fibrinoid necrosis and luminal thrombosis. Agreement analysis was performed using the kappa coefficient. Sensitivity, specificity, positive predictive value (PPV<\/jats:styled-content>), positive likelihood ratio (PLR<\/jats:styled-content>) and 95% confidence interval (95% CI<\/jats:styled-content>) of the useful histopathological features were analysed. Of all 62 biopsies, 28 were cPAN<\/jats:styled-content> and 34 were ST<\/jats:styled-content>. Reproducibility between four observers was in substantial agreement (\u03ba = 0.73). Elastic fibre distribution in the vascular wall (\u03ba = 0.68), fibrinoid necrosis (\u03ba = 0.63), an internal elastic lamina pattern (\u03ba = 0.51) and a smooth muscle arrangement pattern (\u03ba = 0.46) showed high specificity and PPV<\/jats:styled-content> for differentiating between cPAN<\/jats:styled-content> and ST<\/jats:styled-content>. The smooth muscle arrangement pattern, internal elastic lamina pattern and elastic fibre distribution in the vascular wall may be obscured when extensive inflammation and necrosis occurs.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These aforementioned histopathological features are useful in differentiation between cPAN<\/jats:styled-content> and ST<\/jats:styled-content>. The Verhoeff\u2013van Gieson (VVG<\/jats:styled-content>) elastic stain is an important histochemical study for differentiating between cPAN<\/jats:styled-content> and ST<\/jats:styled-content>, particularly in cases with extensive inflammation and necrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13635","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:55:39Z","timestamp":1524185739000},"page":"407-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interobserver reliability of histopathological features for distinguishing between cutaneous polyarteritis nodosa and superficial thrombophlebitis"],"prefix":"10.1111","volume":"73","author":[{"given":"Parnhathai","family":"Hutachuda","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchanan","family":"Hanamornroongruang","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penvadee","family":"Pattanaprichakul","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pattriya","family":"Chanyachailert","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-5787","authenticated-orcid":false,"given":"Panitta","family":"Sitthinamsuwan","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181d7759d"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182770a42"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182157ed1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05394.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00752.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2007.02.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.030"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181766190"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2006.00419.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12809"},{"key":"e_1_2_7_12_1","first-page":"5","article-title":"Arterial versus venous endothelial cells","volume":"1","author":"Paz NG","year":"2009","journal-title":"Cell Tissue Res."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.13635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T10:06:20Z","timestamp":1694945180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.13635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,8]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/his.13635"],"URL":"https:\/\/doi.org\/10.1111\/his.13635","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"type":"print","value":"0309-0167"},{"type":"electronic","value":"1365-2559"}],"subject":[],"published":{"date-parts":[[2018,6,8]]},"assertion":[{"value":"2017-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}