{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:59:32Z","timestamp":1776308372606,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Lung transplant monitoring is usually performed with forceps transbronchial biopsies. These types of biopsy show limited reliability and a high degree of variability, owing to insufficient material and compression artefact, which lead to misinterpretation and, eventually, inappropriate treatment of the transplanted patients. The following study was undertaken to assess the diagnostic yield, histological quality and safety of cryobiopsy (<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>) in comparison with conventional forceps biopsy (<jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>) for sampling lung tissue in transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>From January to December 2011, 81 consecutive transbronchial biopsies (41 <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content>s and 40 <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>s) were indicated in single or bilateral lung transplantation recipients with clinical acute or chronic lung injury. Lung samples obtained by <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> were larger (8.5 \u00b1 6.5 mm in the <jats:styled-content style=\"fixed-case\">FB<\/jats:styled-content> group versus 22.1 \u00b1 12.5 mm in the <jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content> group; <jats:italic>P<\/jats:italic> &lt; 0.0001) and had no crush artefacts (<jats:italic>P<\/jats:italic> = 0.002), allowing us to increase the diagnostic yield of acute (<jats:italic>P<\/jats:italic> = 0.0657) and chronic (<jats:italic>P<\/jats:italic> = 0.0053) cellular rejection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Transbronchial cryoprobe bronchoscopy allows the harvesting of larger and more expanded lung tissue samples, increasing the diagnostic yield in the monitoring of the lung allograft by means of a safe procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13656","type":"journal-article","created":{"date-parts":[[2018,5,20]],"date-time":"2018-05-20T03:54:21Z","timestamp":1526788461000},"page":"593-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The role of transbronchial cryobiopsy in lung transplantation"],"prefix":"10.1111","volume":"73","author":[{"given":"M Angeles","family":"Montero","sequence":"first","affiliation":[{"name":"Department of Histopathology Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"de Gracia","sequence":"additional","affiliation":[{"name":"CIBER Enfermedades Respiratorias (Ciberes) Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Pneumology Service Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Culebras Amigo","sequence":"additional","affiliation":[{"name":"CIBER Enfermedades Respiratorias (Ciberes) Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Pneumology Service Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Mugnier","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"CIBER Enfermedades Respiratorias (Ciberes) Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Pneumology Service Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Berastegui","sequence":"additional","affiliation":[{"name":"CIBER Enfermedades Respiratorias (Ciberes) Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"},{"name":"Pneumology Service Hospital Vall d'Hebron Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-3781","authenticated-orcid":false,"given":"Cristian","family":"Ortiz\u2010Villal\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pathology Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.10.017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03382.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1249117"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203987"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2011.02.008"},{"key":"e_1_2_8_7_1","first-page":"734","article-title":"Transbronchoscopy lung biopsy for diffuse pulmonary disease","volume":"73","author":"Anderson HA","year":"1978","journal-title":"Chest"},{"key":"e_1_2_8_8_1","first-page":"280","article-title":"Comparison of transbronchial and open biopsies in chronic infiltrative lung diseases","volume":"123","author":"Wall CP","year":"1981","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.5.1126"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12322"},{"issue":"5","key":"e_1_2_8_11_1","first-page":"626","article-title":"Prospective study of transbronchial biopsies in the management of heart\u2010lung transplant","volume":"10","author":"Scott JP","year":"1991","journal-title":"J. Heart Lung Transplant."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.111.2.377"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12037"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0294-OA"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13221"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2290"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198905000-00030"},{"key":"e_1_2_8_18_1","first-page":"675","article-title":"The diagnosis of obliterative bronchiolitis after heart\u2010lung and lung transplantation: low yield of transbronchial lung biopsy","volume":"12","author":"Kramer MR","year":"1993","journal-title":"J. Heart Lung Transplant."},{"key":"e_1_2_8_19_1","first-page":"963","article-title":"Evaluation of transbronchial lung biopsy specimens in the diagnosis of bronchiolitis obliterans after lung transplantation","volume":"13","author":"Chamberlain D","year":"1994","journal-title":"J. Heart Lung Transplant."},{"key":"e_1_2_8_20_1","first-page":"137","article-title":"Diagnosis of chronic lung transplants rejection by transbronchial biopsy","volume":"8","author":"Cagle PT","year":"1995","journal-title":"Mod. Pathol."},{"key":"e_1_2_8_21_1","first-page":"761","article-title":"Transbronchial biopsy in heart and lung transplantation: clinicopathologic correlations","volume":"14","author":"Pomerance A","year":"1995","journal-title":"J. Heart Lung Transplant."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000135934"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.13656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T01:43:00Z","timestamp":1695001380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.13656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/his.13656"],"URL":"https:\/\/doi.org\/10.1111\/his.13656","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]},"assertion":[{"value":"2018-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}