{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:16:06Z","timestamp":1778757366944,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/25905\u20101"],"award-info":[{"award-number":["2015\/25905\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/16102\u20108"],"award-info":[{"award-number":["2017\/16102\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Sebaceous carcinomas are uncommon malignant cutaneous tumours originating from the pilosebaceous unit. Although its occurrence is mostly common in peri\u2010ocular glands, other anatomical regions of the head and neck may be affected, including major and minor salivary glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We describe a series of sebaceous adenocarcinomas of the parotid and submandibular glands. The mean age was 62.1 (range = 31\u201390) years. Two patients (20%) presented regional or distant metastasis to mandible and lungs. All cases were positive for cytokeratins (<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>3 and <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>\u20105), epithelial membrane antigen and adipophilin and negative for androgen receptor, Factor <jats:styled-content style=\"fixed-case\">XIII<\/jats:styled-content>a, S\u2010100, vimentin and perforin. <jats:styled-content style=\"fixed-case\">MLH<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content>2 were expressed in the nuclei of most tumour cells, and one case showed loss of <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content>2 expression. Proliferative index (assessed by Ki\u201067 expression) and microvessel density (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>34\u2010positive vessels) were higher in metastasis\u2010associated cases. P63 expression was noted in the periphery of the tumour nests, in the basaloid cells, with a mean of 69.2% nuclear positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The sebaceous adenocarcinoma of salivary glands is rare and may show an unfavourable outcome; therefore, its correct diagnosis may be challenging. For this reason, immunohistochemical studies, including adipophilin in particular, constitute an important diagnostic tool.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13664","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T16:19:19Z","timestamp":1527869959000},"page":"585-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases"],"prefix":"10.1111","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-6640","authenticated-orcid":false,"given":"Ciro D","family":"Soares","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Area of Pathology Piracicaba Dental School University of Campinas Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thayn\u00e1 M L","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Area of Pathology Piracicaba Dental School University of Campinas Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Carlos","sequence":"additional","affiliation":[{"name":"Pathology Division Centro Cl\u00ednico de Cabeza y Cuello\/Hospital Herrera Llerandi Guatemala City Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacks","family":"Jorge","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Area of Pathology Piracicaba Dental School University of Campinas Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oslei Paes","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Area of Pathology Piracicaba Dental School University of Campinas Piracicaba SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G F","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Private Pathology Service Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albina M M","family":"Altemani","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medical Sciences University of Campinas Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.2.383"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.12.025"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.02.007"},{"key":"e_1_2_7_5_1","first-page":"320","article-title":"Sebaceous glands in salivary gland tissue","volume":"98","author":"Linhartova A","year":"1974","journal-title":"Arch. 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