{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:23:42Z","timestamp":1777908222596,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P50 CA095103\u201013"],"award-info":[{"award-number":["5P50 CA095103\u201013"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P30 DK058404\u201013"],"award-info":[{"award-number":["5P30 DK058404\u201013"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Mesenteric tumour deposits frequently occur in small\u2010intestine neuroendocrine tumours. In many instances, these mesenteric tumour deposits are surrounded by a dense fibrotic stroma and have associated lymphoplasmacytic inflammation. The aim of this study was to examine whether mesenteric tumour deposits in patients with small\u2010intestine <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s neuroendocrine tumours show histological and immunophenotypic overlap with IgG4\u2010related sclerosing mesenteritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Sixty\u2010six mesenteric tumour deposits from 66 patients with small\u2010intestine neuroendocrine tumours with blocks available for further studies were identified from our archives. Cases were assessed for clinicopathological features and the presence of IgG4\u2010positive and IgG\u2010positive plasma cells by immunohistochemistry. Ratios of IgG4\u2010positive to IgG\u2010positive plasma cells were calculated. Seventeen mesenteric tumour deposits (26%) showed &gt;40 IgG4\u2010positive plasma cells per high\u2010power field, and the majority of cases (68%) showed at least some staining of IgG4\u2010positive plasma cells. Mesenteric tumour deposits with &gt;20 IgG4\u2010positive plasma cells per high\u2010power field tended to be larger (25.9\u00a0\u00b1\u00a013.0 mm versus 18.6\u00a0\u00b1\u00a015.8\u00a0mm; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.07), and had more IgG\u2010positive plasma cells (88\u00a0\u00b1\u00a024 versus 36\u00a0\u00b1\u00a037; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and a higher IgG4\u2010positive\/IgG\u2010positive plasma cell ratio (0.66\u00a0\u00b1\u00a00.18 versus 0.17\u00a0\u00b1\u00a00.25; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). All but one mesenteric tumour deposit with &gt;20 IgG4\u2010positve plasma cells had a ratio of &gt;40%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IgG4 expression is frequent in mesenteric tumour deposits from small\u2010intestine neuroendocrine tumours. Undersampling of tumour on biopsies of mesenteric tumour deposits could potentially cause diagnostic confusion with IgG4\u2010related sclerosing mesenteritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13693","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:31:13Z","timestamp":1529998273000},"page":"795-800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mesenteric tumour deposits arising from small\u2010intestine neuroendocrine tumours are frequently associated with fibrosis and IgG4\u2010expressing plasma cells"],"prefix":"10.1111","volume":"73","author":[{"given":"Jordan","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-4220","authenticated-orcid":false,"given":"Raul S","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Revetta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5962-6479","authenticated-orcid":false,"given":"Chanjuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31818e4641"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3_31"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20179"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.232"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000751"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.357150066"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2015.12.03"},{"key":"e_1_2_8_10_1","volume-title":"World Health Organization classification of tumours of the digestive system","author":"Bosman FT","year":"2010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.232025081"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0710-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000497"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-017-0716-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-014-0090-4"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.13693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T19:17:03Z","timestamp":1694891823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.13693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,13]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/his.13693"],"URL":"https:\/\/doi.org\/10.1111\/his.13693","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,13]]},"assertion":[{"value":"2018-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}