{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:36:13Z","timestamp":1788878173916,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 26870129"],"award-info":[{"award-number":["JP 26870129"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Uterine adenomatoid tumour (<jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>) is a benign proliferation of cells showing mesothelial differentiation within the myometrium that usually presents as a single nodule. Rare diffuse uterine <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>s have been reported, often in patients undergoing immunosuppressive therapy. Herein, we aimed to elucidate the general association between the incidence of uterine <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> and iatrogenic immunosuppression by cohort analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analysed 611 consecutive hysterectomy specimens to determine the incidence of <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> and its correlation with the immunosuppressive status. Mesothelial lineage, p16 expression, mismatch repair (<jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content>) protein alterations, and the possible integration of tumorigenic viruses were examined by <jats:italic>in\u00a0situ<\/jats:italic> hybridizasion and immunohistochemistry. <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>s were detected in 14 of 611 hysterectomy cases (2.3%). The incidence of <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> was significantly higher in the immunosuppressed (<jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>) group (5\/20, 25.0%) than in the non\u2010<jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> group (9\/591, 1.52%), with a relative risk of 16.4. Of the five <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>s in the <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> group, three were multifocal or diffuse. Latent uterine <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> was detected, by <jats:italic>in toto<\/jats:italic> sectioning, in one of four immunosuppressed autopsy cases. The tumor cells of <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>s commonly expressed calretinin and podoplanin. Characteristic block\u2010type (\u226590%) positivity for p16 was observed in most <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>s. None of the <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>s were positive for human herpes virus type 8, Merkel cell polyomavirus, <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>40 large T antigen, Epstein\u2010Barr virus, and human papilloma virus, and the <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> proteins were retained. A <jats:italic><jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>7<\/jats:italic> mutation was identified from macrodissected tissue in one of 12 <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>s by Sanger sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Uterine <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content> is an immunosuppression\u2010associated mesothelial lesion characterised by p16 overexpression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13726","type":"journal-article","created":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T00:59:35Z","timestamp":1534035575000},"page":"1013-1022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Adenomatoid tumour of the uterus is frequently associated with iatrogenic 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