{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:25:47Z","timestamp":1782167147249,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,4]],"date-time":"2018-11-04T00:00:00Z","timestamp":1541289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CAPES and FAPESP","award":["#2015\/25905-1 and #2017\/16102-8"],"award-info":[{"award-number":["#2015\/25905-1 and #2017\/16102-8"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Fibroblast growth factor (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>)\u20102 and fibroblast growth factor receptor (<jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>)\u20101 are associated with tumour invasiveness, cell proliferation, angiogenesis, and metastasis. The aims of this study were to investigate <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 expression and <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>\u20101 expression in oral epithelial dysplasia (<jats:styled-content style=\"fixed-case\">OED<\/jats:styled-content>) and oral tongue squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>), and their correlation with <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content> patients\u2019 prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>One hundred and sixty\u2010seven cases were retrospectively selected, including 85 surgical specimens of patients with <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>, 46 incisional biopsies of <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>, and 36 incisional biopsies of <jats:styled-content style=\"fixed-case\">OED<\/jats:styled-content>. Tissue sections were subjected to immunohistochemical staining for <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>\u20101, and digitally scored. Elevated scores of <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>\u20101 immunostaining were associated with high\u2010grade <jats:styled-content style=\"fixed-case\">OED<\/jats:styled-content>s. <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 positivity in the stroma was associated with vascular invasion and a worse prognosis, in both overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) analyses, in univariate and multivariate models. <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>\u20101 positivity in the stroma was correlated with lymph node metastasis and distant metastasis. <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>\u20101 expression in either the malignant cells or the stroma was strongly correlated with shorter <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together, our findings suggest that increased <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 expression and increased <jats:styled-content style=\"fixed-case\">FGFR<\/jats:styled-content>\u20101 expression are associated with high\u2010grade <jats:styled-content style=\"fixed-case\">OED<\/jats:styled-content>s, and are correlated with the presence of metastasis and adverse outcomes in <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13739","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:48:43Z","timestamp":1534952923000},"page":"311-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<scp>FGF<\/scp>\u20102 and <scp>FGFR<\/scp>\u20101 might be independent prognostic factors in oral tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8036-0705","authenticated-orcid":false,"given":"Bruno A L A","family":"Mariz","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis Piracicaba Dental School University of Campinas Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-6640","authenticated-orcid":false,"given":"Ciro D","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Oral 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