{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:46:21Z","timestamp":1785681981608,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T00:00:00Z","timestamp":1543708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271040"],"award-info":[{"award-number":["31271040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270176"],"award-info":[{"award-number":["81270176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 is known as an essential transcription factor for regulating neurogenesis. Recently, <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 has been suggested to be a diagnostic marker and oncogene because of its significant expression in mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>). However, <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 expression in other tumour types has not yet been extensively studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Herein, we examined <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 expression in 2026 cases of neuroectodermal, germ cell, mesenchymal and epithelial tumours by immunohistochemistry. <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 was consistently expressed in all neuroectodermal tumours with neural differentiation, as well as in immature teratomas revealing neurogenesis. Less frequently, <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 expression was observed in only 50% of astrocytomas and 24% of malignant peripheral nerve sheath tumours, and was mainly sporadic and weak\/intermediate. In epithelial tumours, significant <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 expression was identified in 97% of salivary ductal carcinomas (<jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content>s) and a high percentage of high\u2010grade neuroendocrine carcinomas (<jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>s), especially the small\u2010cell lung carcinomas (68%), and was absent in most other carcinomas, except for less and\/or focal and weak expression in adenocarcinomas from the lung, genital tract and breast, and salivary adenoid cystic carcinomas and epithelial\u2013myoepithelial carcinomas. In mesenchymal tumours, in addition to <jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>s, prominent <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 expression was observed in 90% of rhabdomyosarcomas and all myxoid\/round cell liposarcomas (<jats:styled-content style=\"fixed-case\">MRCL<\/jats:styled-content>s). Less frequent and\/or focal and weak expression was observed in lymphoblastic, Burkitt and follicular lymphomas, synovial sarcoma and angiosarcoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 showed prominent expression in neuroectodermal tumours with neural differentiation, high grade\u2010<jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SDC<\/jats:styled-content>, rhabdomyosarcoma and <jats:styled-content style=\"fixed-case\">MRCL<\/jats:styled-content>. The high sensitivity and specificity of <jats:styled-content style=\"fixed-case\">SOX<\/jats:styled-content>11 in <jats:styled-content style=\"fixed-case\">SDC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRCL<\/jats:styled-content> make it a useful diagnostic marker.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13757","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T11:29:28Z","timestamp":1537183768000},"page":"391-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["SOX11: a potentially useful marker in surgical pathology: a systematic analysis of <scp>SOX<\/scp>11 expression in epithelial and non\u2010epithelial tumours"],"prefix":"10.1111","volume":"74","author":[{"given":"Sanpeng","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Pathology Tongji Hospital Huazhong University of Science and Technology Wuhan 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