{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:12:40Z","timestamp":1789776760706,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271743"],"award-info":[{"award-number":["81271743"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571969"],"award-info":[{"award-number":["81571969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Persistent pruritic eruptions (<jats:styled-content style=\"fixed-case\">PPE<\/jats:styled-content>s), presenting with dyskeratotic keratinocytes histologically, are characteristic skin rash in patients with adult\u2010onset Still's disease (<jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>). The lesions may be histologically similar to other entities that present with dyskeratosis. In the present study, we compared the histopathological features between <jats:styled-content style=\"fixed-case\">PPE<\/jats:styled-content>s and other entities presenting with dyskeratosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>To investigate whether histopathological findings can be used to discriminate among <jats:styled-content style=\"fixed-case\">PPE<\/jats:styled-content>s and other entities presenting with dyskeratotic keratinocytes, cutaneous histopathological changes of <jats:styled-content style=\"fixed-case\">PPE<\/jats:styled-content>s associated with <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) were compared with those of systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a016), dermatomyositis (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), and drug eruption (<jats:italic>n<\/jats:italic>\u00a0=\u00a016). Dyskeratosis was observed in the upper one\u2010third of the epidermal layer in all 26 <jats:styled-content style=\"fixed-case\">PPE<\/jats:styled-content>s. The rate of dyskeratosis for <jats:styled-content style=\"fixed-case\">PPE<\/jats:styled-content>s was higher than that for <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> (18.8%) and dermatomyositis (15.8%). In drug eruptions, the dyskeratotic cells were distributed in all levels of the epidermis. Variable densities of neutrophils were found in the dermis in all <jats:styled-content style=\"fixed-case\">PPE<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although this was a retrospective study conducted at a single centre, presentation of dyskeratotic keratinocytes in the upper one\u2010third of the epidermal layer is a distinctive histopathological reactive pattern of <jats:styled-content style=\"fixed-case\">PPE<\/jats:styled-content>s. This pattern may be a useful histopathological marker for early diagnosis of <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13785","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T19:42:31Z","timestamp":1541706151000},"page":"759-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Histopathological diagnosis of persistent pruritic eruptions associated with adult\u2010onset Still's disease"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3386-297X","authenticated-orcid":false,"given":"Jianjun","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Dermatology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 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