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Here, both characteristics of the tumour and its microenvironment were examined and a novel prognostic model has been proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A total of 246 patients with <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> were included. Using H&amp;E\u2010stained sections, pathological parameters of tumour and the <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content> were assessed. Inflammatory response (i), tumour budding (B) and invasive depth (D) were combined as <jats:styled-content style=\"fixed-case\">iBD<\/jats:styled-content> score. The association between these variables and the patient survival was determined. Both tumour budding and inflammatory status were independent variables for predicting overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> patients. Invasive depth was correlated with differentiation, T classification, lymph node metastasis, clinical stage and recurrence (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The novel <jats:styled-content style=\"fixed-case\">iBD<\/jats:styled-content> model was strongly correlated with T classification, lymph node metastasis, clinical stage and recurrence, and showed clear distinction of scores 0, 1 and 2. High <jats:styled-content style=\"fixed-case\">iBD<\/jats:styled-content> score had a strong association with reduced <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">iBD<\/jats:styled-content> scoring model is strongly associated with lymph node metastasis and recurrence in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> and could be a promising survival predictor for <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13790","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T15:54:35Z","timestamp":1542383675000},"page":"766-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score"],"prefix":"10.1111","volume":"74","author":[{"given":"Pei","family":"Yu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"},{"name":"Department of Oral Maxillofacial Surgery Guanghua School of Stomatology and Hospital of Stomatology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwang","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Stomatology Guangzhou China"},{"name":"Department of 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